Convenient and general palladium-catalyzed carbonylative sonogashira coupling of aryl amines

Xiao Feng Wu, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Bar (alky)none: A general and efficient method for carbonylative Sonogashira coupling reactions of anilines to generate alkynones has been developed (see scheme; TFP=tri(2-furyl)phosphine). The reaction proceeds under mild conditions and no base is needed.

Original languageEnglish
Pages (from-to)11142-11146
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume50
Issue number47
DOIs
StatePublished - 18 Nov 2011
Externally publishedYes

Keywords

  • cross-coupling
  • domino reactions
  • heterocycles
  • palladium
  • synthetic methods

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