Controlling selectivity: From Markovnikov to anti-Markovnikov hydroamination of alkynes

Annegret Tillack, Vivek Khedkar, Matthias Beller

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

A remarkable control of regioselectivity is achieved for the titanium-catalyzed intermolecular hydroamination of various alkynes. Proper choice of the ligand enables a selectivity switch from the Markovnikov to the anti-Markovnikov products from M:anti-M = > 90:10 to >10:90. Depending on the catalyst a remarkable control of regioselectivity is achieved for the titanium-catalyzed intermolecular hydroamination of various alkynes. Proper choice of sterically hindered phenol ligands such as 1 and 4 enables a selectivity switch from the Markovnikov to the anti-Markovnikov products from M:anti-M = > 90:10 to > 10:90.

Original languageEnglish
Pages (from-to)8875-8878
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number48
DOIs
StatePublished - 22 Nov 2004
Externally publishedYes

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