Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands

  • R. Fraioli
  • , S. Neubauer
  • , F. Rechenmacher
  • , B. M. Bosch
  • , K. Dashnyam
  • , J. H. Kim
  • , R. A. Perez
  • , H. W. Kim
  • , F. J. Gil
  • , M. P. Ginebra
  • , J. M. Manero
  • , H. Kessler
  • , C. Mas-Moruno

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

In this communication we report that anchoring αvβ3 or α5β1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.

Original languageEnglish
Pages (from-to)1281-1285
Number of pages5
JournalBiomaterials Science
Volume7
Issue number4
DOIs
StatePublished - Apr 2019

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