Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands

R. Fraioli, S. Neubauer, F. Rechenmacher, B. M. Bosch, K. Dashnyam, J. H. Kim, R. A. Perez, H. W. Kim, F. J. Gil, M. P. Ginebra, J. M. Manero, H. Kessler, C. Mas-Moruno

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

In this communication we report that anchoring αvβ3 or α5β1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.

Original languageEnglish
Pages (from-to)1281-1285
Number of pages5
JournalBiomaterials Science
Volume7
Issue number4
DOIs
StatePublished - Apr 2019

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