Control of hepatitis B virus by cytokines

Yuchen Xia; Ulrike Protzer

doi:10.3390/v9010018

Control of hepatitis B virus by cytokines

Yuchen Xia, Ulrike Protzer

Chair of Virology

Research output: Contribution to journal › Review article › peer-review

103 Scopus citations

Abstract

Hepatitis B virus (HBV) infection remains a major public health problem worldwide with more than 240 million individuals chronically infected. Current treatments can control HBV replication to a large extent, but cannot eliminate HBV infection. Cytokines have been shown to control HBV replication and contribute to HBV cure in different models. Cytokines play an important role in limiting acute HBV infection in patients and mediate a non-cytolytic clearance of the virus. In this review, we summarize the effects of cytokines and cytokine-induced cellular signaling pathways on different steps of the HBV life cycle, and discuss possible strategies that may contribute to the eradication of HBV through innate immune activation.

Original language	English
Article number	18
Journal	Viruses
Volume	9
Issue number	1
DOIs	https://doi.org/10.3390/v9010018
State	Published - 20 Jan 2017

Keywords

CccDNA
Cytokine
Hepatitis B virus (HBV)
Interferon
Interferon-induced gene (ISG)
Therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/v9010018

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title = "Control of hepatitis B virus by cytokines",

abstract = "Hepatitis B virus (HBV) infection remains a major public health problem worldwide with more than 240 million individuals chronically infected. Current treatments can control HBV replication to a large extent, but cannot eliminate HBV infection. Cytokines have been shown to control HBV replication and contribute to HBV cure in different models. Cytokines play an important role in limiting acute HBV infection in patients and mediate a non-cytolytic clearance of the virus. In this review, we summarize the effects of cytokines and cytokine-induced cellular signaling pathways on different steps of the HBV life cycle, and discuss possible strategies that may contribute to the eradication of HBV through innate immune activation.",

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author = "Yuchen Xia and Ulrike Protzer",

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AU - Xia, Yuchen

AU - Protzer, Ulrike

PY - 2017/1/20

Y1 - 2017/1/20

N2 - Hepatitis B virus (HBV) infection remains a major public health problem worldwide with more than 240 million individuals chronically infected. Current treatments can control HBV replication to a large extent, but cannot eliminate HBV infection. Cytokines have been shown to control HBV replication and contribute to HBV cure in different models. Cytokines play an important role in limiting acute HBV infection in patients and mediate a non-cytolytic clearance of the virus. In this review, we summarize the effects of cytokines and cytokine-induced cellular signaling pathways on different steps of the HBV life cycle, and discuss possible strategies that may contribute to the eradication of HBV through innate immune activation.

AB - Hepatitis B virus (HBV) infection remains a major public health problem worldwide with more than 240 million individuals chronically infected. Current treatments can control HBV replication to a large extent, but cannot eliminate HBV infection. Cytokines have been shown to control HBV replication and contribute to HBV cure in different models. Cytokines play an important role in limiting acute HBV infection in patients and mediate a non-cytolytic clearance of the virus. In this review, we summarize the effects of cytokines and cytokine-induced cellular signaling pathways on different steps of the HBV life cycle, and discuss possible strategies that may contribute to the eradication of HBV through innate immune activation.

KW - CccDNA

KW - Cytokine

KW - Hepatitis B virus (HBV)

KW - Interferon

KW - Interferon-induced gene (ISG)

KW - Therapy

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DO - 10.3390/v9010018

M3 - Review article

C2 - 28117695

AN - SCOPUS:85010830980

SN - 1999-4915

VL - 9

JO - Viruses

JF - Viruses

IS - 1

M1 - 18

ER -

Control of hepatitis B virus by cytokines

Abstract

Keywords

UN SDGs

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