Control of frictional coupling of transmembrane cell receptors in model cell membranes with linear polymer spacers

Oliver Purrucker, Anton Förtig, Rainer Jordan, Erich Sackmann, Motomu Tanaka

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The planar plasma membrane model with linear polymer spacers with defined lengths enables the control of the frictional coupling between incorporated transmembrane proteins (human platelet integrin) and the solid substrate. This mimics the viscous environment provided by the extracellular matrix of cells. The friction coefficient can be calculated quantitatively from the diffusion coefficient of integrin, measured by fluorescence recovery after photobleaching. The obtained results demonstrate a clear influence of the length and lateral density of polymer chains on the mobility of transmembrane proteins.

Original languageEnglish
Article number078102
JournalPhysical Review Letters
Volume98
Issue number7
DOIs
StatePublished - 12 Feb 2007

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