@inproceedings{97f5c56acf114b279fa1ed8924495fdd,
title = "Control-architecture for cell-based high-content and high throughput screening",
abstract = "Addressing the rising interest in biomedical and pharmacological high-content screening assays, a concept has been developed, which integrates automated imaging, multi-parametric sensor readout and probe handling into a single embedded platform (IMR). This paper describes the real-time automated microscopy capabilities of the IMR: Utilizing a topology of distributed intelligences and hardwarebased synchronization, the platform concept allows precisely timed and synchronized operation of all integrated platform components. Hardware level synchronization is achieved by means of a newly developed, highly modular digital signal processor based “Integration Control Unit”, which runs a real time environment and provides standard electrical interfaces to connect to other platform components. Being suitable for high-content and high-throughput analytical screening, the automated platform may thus develop into an enabling technology for future screening assays, especially in the field of pharmacological drug screening.",
keywords = "Automated imaging, Bio-sensors, Cell-based assays, Fluorescence microscopy, Real time performance",
author = "Thomas Geisler and V. Lob and B. Wolf and Rainer Uhl",
note = "Publisher Copyright: {\textcopyright} International Federation for Medical and Biological Engineering 2007.; 10th World Congress on Medical Physics and Biomedical Engineering, WC 2006 ; Conference date: 27-08-2006 Through 01-09-2006",
year = "2007",
doi = "10.1007/978-3-540-36841-0_572",
language = "English",
isbn = "9783540368397",
series = "IFMBE Proceedings",
publisher = "Springer Verlag",
number = "1",
pages = "2268--2271",
editor = "Kim, {Sun I.} and Suh, {Tae Suk}",
booktitle = "IFMBE Proceedings",
edition = "1",
}