TY - JOUR
T1 - Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers
AU - Graeser, Monika K.
AU - Engel, Christoph
AU - Rhiem, Kerstin
AU - Gadzicki, Dorothea
AU - Bick, Ulrich
AU - Kast, Karin
AU - Froster, Ursula G.
AU - Schlehe, Bettina
AU - Bechtold, Astrid
AU - Arnold, Norbert
AU - Preisler-Adams, Sabine
AU - Nestle-Kraemling, Carolin
AU - Zaino, Mohammad
AU - Loeffler, Markus
AU - Kiechle, Marion
AU - Meindl, Alfons
AU - Varga, Dominic
AU - Schmutzler, Rita K.
PY - 2009/12/10
Y1 - 2009/12/10
N2 - Purpose: To estimate the risk for contralateral breast cancer in members of BRCA1- and BRCA2-positive families and to determine predictive risk factors. Patients and Methods: A retrospective, multicenter, cohort study was performed from 1996 until 2008 and comprised 2,020 women with unilateral breast cancer (index patients, n = 978; relatives, n = 1.42) from 978 families who had a BRCA1 or BRCA2 mutation. Cox regression analysis was applied to assess the association of age at first breast cancer with time from first to contralateral breast cancer, stratified by the affected BRCA gene. Results: The cumulative risk for contralateral breast cancer 25 years after first breast cancer was 47.4% (95% CI, 38.8% to 56.0%) for patients from families with BRCA1 or BRCA2 mutations. Members of families with BRCA1 mutations had a 1.6-fold (95% CI, 1.2-fold to 2.3-fold) higher risk of contralateral breast cancer than members of families with BRCA2 mutations. Younger age at first breast cancer was associated with a significantly higher risk of contralateral breast cancer in patients with BRCA1 mutation, and a trend was observed in patients with BRCA2 mutation. After 25 years, 62.9% (95% CI, 50.4% to 75.4%) of patients with BRCA1 mutation who were younger than 40 years of age at first breast cancer developed contralateral breast cancer, compared with only 19.6% (95% CI, 5.3% to 33.9%) of those who were older than 50 years of age at first breast cancer. Conclusion: Contralateral breast cancer risk depends on age at first breast cancer and on the affected BRCA gene, and this risk should be considered in treatment planning.
AB - Purpose: To estimate the risk for contralateral breast cancer in members of BRCA1- and BRCA2-positive families and to determine predictive risk factors. Patients and Methods: A retrospective, multicenter, cohort study was performed from 1996 until 2008 and comprised 2,020 women with unilateral breast cancer (index patients, n = 978; relatives, n = 1.42) from 978 families who had a BRCA1 or BRCA2 mutation. Cox regression analysis was applied to assess the association of age at first breast cancer with time from first to contralateral breast cancer, stratified by the affected BRCA gene. Results: The cumulative risk for contralateral breast cancer 25 years after first breast cancer was 47.4% (95% CI, 38.8% to 56.0%) for patients from families with BRCA1 or BRCA2 mutations. Members of families with BRCA1 mutations had a 1.6-fold (95% CI, 1.2-fold to 2.3-fold) higher risk of contralateral breast cancer than members of families with BRCA2 mutations. Younger age at first breast cancer was associated with a significantly higher risk of contralateral breast cancer in patients with BRCA1 mutation, and a trend was observed in patients with BRCA2 mutation. After 25 years, 62.9% (95% CI, 50.4% to 75.4%) of patients with BRCA1 mutation who were younger than 40 years of age at first breast cancer developed contralateral breast cancer, compared with only 19.6% (95% CI, 5.3% to 33.9%) of those who were older than 50 years of age at first breast cancer. Conclusion: Contralateral breast cancer risk depends on age at first breast cancer and on the affected BRCA gene, and this risk should be considered in treatment planning.
UR - http://www.scopus.com/inward/record.url?scp=73349132056&partnerID=8YFLogxK
U2 - 10.1200/JCO.2008.19.9430
DO - 10.1200/JCO.2008.19.9430
M3 - Article
C2 - 19858402
AN - SCOPUS:73349132056
SN - 0732-183X
VL - 27
SP - 5887
EP - 5892
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 35
ER -