Continuous-Flow Synthesis and Functionalization of Magnetite: Intensified Process for Tailored Nanoparticles

Franz Haseidl, Barbara Müller, Olaf Hinrichsen

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The spinning disc reactor (SDR) is used for the size-selective synthesis and functionalization of nanoscale superparamagnetic iron oxide particles in a single-step continuous-flow process. Nanometer-sized magnetite (Fe3O4) particles are precipitated in a highly sheared thin liquid film on a rapidly rotating disc. A novel liquid-liquid synthesis is presented whereas control over particle size is reached via adjustable micromixing properties on the disc. The nanoparticles with tailored size, narrow size distribution, and high saturation magnetization can thus meet the special requirements for the use in biotechnological, medical, and catalytic applications. The functionalization of the particles with oleic acid for higher biocompatibility and better dispersibility is accomplished in the SDR in a single step.

Original languageEnglish
Pages (from-to)2051-2058
Number of pages8
JournalChemical Engineering and Technology
Issue number11
StatePublished - 1 Nov 2016


  • Controlled mixing
  • Liquid-liquid synthesis
  • Magnetite nanoparticles
  • Process intensification
  • Spinning disc reactor


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