Contamination-Free Switch Design and Synthesis for Microfluidic Large-Scale Integration

Duan Shen, Yushen Zhang, Mengchu Li, Tsun Ming Tseng, Ulf Schlichtmann

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Microfluidic large-scale integration (mLSI) biochips have developed rapidly in recent decades. The gap between design efficiency and application complexity has led to a growing interest in mLSI design automation. The state-of-the-art design automation tools for mLSI focus on the simultaneous co-optimisation of the flow and control layers but neglect potential contamination between different fluid reagents and products. Microfluidic switches, as fluid routers at the intersection of flow paths, are especially prone to contamination. State-of-the-art tools design the switches as spines with junctions, which aggregate the contamination problem. In this work, we present a contamination-free microfluidic switch design and a synthesis method to generate application-specific switches that can be employed by physical design tools for mLSI. We also propose a scheduling and binding method to transport the fluids with least time and fewest resources. To reduce the number of pressure inlets, we consider pressure sharing between valves within the switch. Experimental results demonstrate that our methods show advantages in avoiding contamination and improving transportation efficiency over conventional methods.

Original languageEnglish
Title of host publicationProceedings of the 2022 Design, Automation and Test in Europe Conference and Exhibition, DATE 2022
EditorsCristiana Bolchini, Ingrid Verbauwhede, Ioana Vatajelu
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages646-651
Number of pages6
ISBN (Electronic)9783981926361
DOIs
StatePublished - 2022
Event2022 Design, Automation and Test in Europe Conference and Exhibition, DATE 2022 - Virtual, Online, Belgium
Duration: 14 Mar 202223 Mar 2022

Publication series

NameProceedings of the 2022 Design, Automation and Test in Europe Conference and Exhibition, DATE 2022

Conference

Conference2022 Design, Automation and Test in Europe Conference and Exhibition, DATE 2022
Country/TerritoryBelgium
CityVirtual, Online
Period14/03/2223/03/22

Keywords

  • contamination
  • design automation
  • microfluidic large-scale integration
  • quadratic linear programming

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