Contamination-Aware Synthesis for Programmable Microfluidic Devices

Programmable microfluidic devices (PMDs) have emerged as a new software-controlled architecture for next-generation flow-based biochips. These devices can be dynamically reconfigured to perform different bioassays flexibly and efficiently owing to their 2-D regularly arranged valve structure. However, PMDs are confronted with critical contamination issues due to the matrix-like structure with intersecting channels. In this article, a block-flushing method is proposed for contamination removal, based on which an overall contamination-aware synthesis flow is proposed. In the proposed block-flushing approach, contaminated areas are first collected according to specific patterns and then flushed as a whole to increase washing efficiency. Then, the synthesis flow integrating the block-flushing method is further optimized such that functional bioassay operations and washing operations can be performed simultaneously for higher efficiency. Experimental results demonstrate that the proposed washing approach reduces the washing time by 28% on commonly used bioassays. Equipped with the proposed washing method, our contamination-aware synthesis flow effectively reduces 30% of the completion time of the bioassays compared with the baseline method.