Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer

Kerstin Rhiem; Bernd Auber; Susanne Briest; Nicola Dikow; Nina Ditsch; Neda Dragicevic; Sabine Grill; Eric Hahnen; Judit Horvath; Bernadette Jaeger; Karin Kast; Marion Kiechle; Elena Leinert; Susanne Morlot; Michael Püsken; Dieter Schäfer; Sarah Schott; Christopher Schroeder; Ulrike Siebers-Renelt; Christine Solbach; Nana Weber-Lassalle; Isabell Witzel; Christine Zeder-Göß; Rita K. Schmutzler

doi:10.1159/000516376

Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer

Kerstin Rhiem, Bernd Auber, Susanne Briest, Nicola Dikow, Nina Ditsch, Neda Dragicevic, Sabine Grill, Eric Hahnen, Judit Horvath, Bernadette Jaeger, Karin Kast, Marion Kiechle, Elena Leinert, Susanne Morlot, Michael Püsken, Dieter Schäfer, Sarah Schott, Christopher Schroeder, Ulrike Siebers-Renelt, Christine SolbachNana Weber-Lassalle, Isabell Witzel, Christine Zeder-Göß, Rita K. Schmutzler

Chair of Gynaecology

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer. Summary: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process. Key Messages: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures.

Original language	English
Pages (from-to)	199-207
Number of pages	9
Journal	Breast Care
Volume	17
Issue number	2
DOIs	https://doi.org/10.1159/000516376
State	Published - 1 Apr 2022

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10.1159/000516376

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Rhiem, K., Auber, B., Briest, S., Dikow, N., Ditsch, N., Dragicevic, N., Grill, S., Hahnen, E., Horvath, J., Jaeger, B., Kast, K., Kiechle, M., Leinert, E., Morlot, S., Püsken, M., Schäfer, D., Schott, S., Schroeder, C., Siebers-Renelt, U., ... Schmutzler, R. K. (2022). Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer. Breast Care, 17(2), 199-207. https://doi.org/10.1159/000516376

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title = "Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer",

abstract = "Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk{\textregistered}) for the analysis of risk genes for familial breast and ovarian cancer. Summary: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process. Key Messages: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures.",

author = "Kerstin Rhiem and Bernd Auber and Susanne Briest and Nicola Dikow and Nina Ditsch and Neda Dragicevic and Sabine Grill and Eric Hahnen and Judit Horvath and Bernadette Jaeger and Karin Kast and Marion Kiechle and Elena Leinert and Susanne Morlot and Michael P{\"u}sken and Dieter Sch{\"a}fer and Sarah Schott and Christopher Schroeder and Ulrike Siebers-Renelt and Christine Solbach and Nana Weber-Lassalle and Isabell Witzel and Christine Zeder-G{\"o}{\ss} and Schmutzler, {Rita K.}",

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year = "2022",

month = apr,

day = "1",

doi = "10.1159/000516376",

language = "English",

volume = "17",

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Rhiem, K, Auber, B, Briest, S, Dikow, N, Ditsch, N, Dragicevic, N, Grill, S, Hahnen, E, Horvath, J, Jaeger, B, Kast, K, Kiechle, M, Leinert, E, Morlot, S, Püsken, M, Schäfer, D, Schott, S, Schroeder, C, Siebers-Renelt, U, Solbach, C, Weber-Lassalle, N, Witzel, I, Zeder-Göß, C & Schmutzler, RK 2022, 'Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer', Breast Care, vol. 17, no. 2, pp. 199-207. https://doi.org/10.1159/000516376

TY - JOUR

T1 - Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer

AU - Rhiem, Kerstin

AU - Auber, Bernd

AU - Briest, Susanne

AU - Dikow, Nicola

AU - Ditsch, Nina

AU - Dragicevic, Neda

AU - Grill, Sabine

AU - Hahnen, Eric

AU - Horvath, Judit

AU - Jaeger, Bernadette

AU - Kast, Karin

AU - Kiechle, Marion

AU - Leinert, Elena

AU - Morlot, Susanne

AU - Püsken, Michael

AU - Schäfer, Dieter

AU - Schott, Sarah

AU - Schroeder, Christopher

AU - Siebers-Renelt, Ulrike

AU - Solbach, Christine

AU - Weber-Lassalle, Nana

AU - Witzel, Isabell

AU - Zeder-Göß, Christine

AU - Schmutzler, Rita K.

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer. Summary: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process. Key Messages: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures.

AB - Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer. Summary: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process. Key Messages: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures.

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U2 - 10.1159/000516376

DO - 10.1159/000516376

M3 - Review article

AN - SCOPUS:85111644561

SN - 1661-3791

VL - 17

SP - 199

EP - 207

JO - Breast Care

JF - Breast Care

IS - 2

ER -

Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer

Abstract

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