Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer

Kerstin Rhiem, Bernd Auber, Susanne Briest, Nicola Dikow, Nina Ditsch, Neda Dragicevic, Sabine Grill, Eric Hahnen, Judit Horvath, Bernadette Jaeger, Karin Kast, Marion Kiechle, Elena Leinert, Susanne Morlot, Michael Püsken, Dieter Schäfer, Sarah Schott, Christopher Schroeder, Ulrike Siebers-Renelt, Christine SolbachNana Weber-Lassalle, Isabell Witzel, Christine Zeder-Göß, Rita K. Schmutzler

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer. Summary: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process. Key Messages: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures.

Original languageEnglish
Pages (from-to)199-207
Number of pages9
JournalBreast Care
Volume17
Issue number2
DOIs
StatePublished - 1 Apr 2022
Externally publishedYes

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