TY - JOUR
T1 - Consensus guidelines for lumbar puncture in patients with neurological diseases
AU - Engelborghs, Sebastiaan
AU - Niemantsverdriet, Ellis
AU - Struyfs, Hanne
AU - Blennow, Kaj
AU - Brouns, Raf
AU - Comabella, Manuel
AU - Dujmovic, Irena
AU - van der Flier, Wiesje
AU - Frölich, Lutz
AU - Galimberti, Daniela
AU - Gnanapavan, Sharmilee
AU - Hemmer, Bernhard
AU - Hoff, Erik
AU - Hort, Jakub
AU - Iacobaeus, Ellen
AU - Ingelsson, Martin
AU - Jan de Jong, Frank
AU - Jonsson, Michael
AU - Khalil, Michael
AU - Kuhle, Jens
AU - Lleó, Alberto
AU - de Mendonça, Alexandre
AU - Molinuevo, José Luis
AU - Nagels, Guy
AU - Paquet, Claire
AU - Parnetti, Lucilla
AU - Roks, Gerwin
AU - Rosa-Neto, Pedro
AU - Scheltens, Philip
AU - Skårsgard, Constance
AU - Stomrud, Erik
AU - Tumani, Hayrettin
AU - Visser, Pieter Jelle
AU - Wallin, Anders
AU - Winblad, Bengt
AU - Zetterberg, Henrik
AU - Duits, Flora
AU - Teunissen, Charlotte E.
N1 - Publisher Copyright:
© 2017 The Authors
PY - 2017
Y1 - 2017
N2 - Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III). Results Our consensus guidelines address contraindications, as well as patient-related and procedure-related risk factors that can influence the development of post-LP complications. Discussion When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.
AB - Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III). Results Our consensus guidelines address contraindications, as well as patient-related and procedure-related risk factors that can influence the development of post-LP complications. Discussion When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.
KW - Back pain
KW - Cerebrospinal fluid
KW - Consensus guidelines
KW - Evidence-based guidelines
KW - Headache
KW - Lumbar puncture
KW - Post-LP complications
UR - http://www.scopus.com/inward/record.url?scp=85020024963&partnerID=8YFLogxK
U2 - 10.1016/j.dadm.2017.04.007
DO - 10.1016/j.dadm.2017.04.007
M3 - Article
AN - SCOPUS:85020024963
SN - 2352-8729
VL - 8
SP - 111
EP - 126
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
ER -
