Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17-21 for the oligomerization state and bioactivity of hCt

Keyphrases

• Bioactivity 100%
• Conformationally Constrained 100%
• Oligomeric State 100%
• Human Calcitonin 100%
• Calcitonin Receptor 16%
• Lactams 11%
• In Vivo Bioactivity 11%
• Receptor Binding Affinity 11%
• Side Chain 5%
• Structure Function 5%
• Topological Features 5%
• The Self 5%
• D-amino Acids 5%
• CD Spectroscopy 5%
• High Potency 5%
• Receptor Affinity 5%
• Denaturation 5%
• Bone Resorption 5%
• Conformational Characteristics 5%
• Calcitonin 5%
• Peptide Hormone 5%
• Partial Sequence 5%
• Solution Conformation 5%
• Novel Analogues 5%
• Osteoporosis Treatment 5%
• Bone Disorders 5%
• Bearing Type 5%
• Cyclic Analogs 5%
• Association State 5%

Biochemistry, Genetics and Molecular Biology

• Oligomerization 100%
• Biological Activity 100%
• Calcitonin 100%
• Receptor Binding 15%
• Calcitonin Receptor 15%
• Conformation 10%
• Agonist 10%
• Binding Affinity 10%
• Solution and Solubility 5%
• Peptide Sequence 5%
• Amino Acids 5%
• Structure Activity Relation 5%
• Denaturation 5%
• Receptor Affinity 5%
• Peptide Hormone 5%
• Circular Dichroism 5%
• Osteolysis 5%