Conformational Prerequisites for the in vitro Inhibition of Cholate Uptake in Hepatocytes by Cyclic Analogues of Antamanide and Somatostatin

Horst Kessler; Mechtild Klein; Arndt Müller; Klaus Wagner; Jan Willem Bats; Kornelia Ziegler; Max Frimmer

doi:10.1002/anie.198609971

Conformational Prerequisites for the in vitro Inhibition of Cholate Uptake in Hepatocytes by Cyclic Analogues of Antamanide and Somatostatin

Horst Kessler
, Mechtild Klein
, Arndt Müller
, Klaus Wagner
, Jan Willem Bats
, Kornelia Ziegler
, Max Frimmer

Johann Wolfgang Goethe University
Justus-Liebig-Universität Gießen

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Constitution and conformation determine the biological activity of a peptide, as demonstrated by comparative investigations of the inhibition of cholate uptake in liver cells by somatostatin, antamanide, cyclolinopeptide A and 1 and 2. The crystal structure of 1 is the same as that of 2 over a wide range and both react strongly cytoprotectively. (Figure Presented.)

Original language	English
Pages (from-to)	997-999
Number of pages	3
Journal	Angewandte Chemie International Edition in English
Volume	25
Issue number	11
DOIs	https://doi.org/10.1002/anie.198609971
State	Published - Nov 1986
Externally published	Yes

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10.1002/anie.198609971

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title = "Conformational Prerequisites for the in vitro Inhibition of Cholate Uptake in Hepatocytes by Cyclic Analogues of Antamanide and Somatostatin",

abstract = "Constitution and conformation determine the biological activity of a peptide, as demonstrated by comparative investigations of the inhibition of cholate uptake in liver cells by somatostatin, antamanide, cyclolinopeptide A and 1 and 2. The crystal structure of 1 is the same as that of 2 over a wide range and both react strongly cytoprotectively. (Figure Presented.)",

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T1 - Conformational Prerequisites for the in vitro Inhibition of Cholate Uptake in Hepatocytes by Cyclic Analogues of Antamanide and Somatostatin

AU - Kessler, Horst

AU - Klein, Mechtild

AU - Müller, Arndt

AU - Wagner, Klaus

AU - Bats, Jan Willem

AU - Ziegler, Kornelia

AU - Frimmer, Max

PY - 1986/11

Y1 - 1986/11

N2 - Constitution and conformation determine the biological activity of a peptide, as demonstrated by comparative investigations of the inhibition of cholate uptake in liver cells by somatostatin, antamanide, cyclolinopeptide A and 1 and 2. The crystal structure of 1 is the same as that of 2 over a wide range and both react strongly cytoprotectively. (Figure Presented.)

AB - Constitution and conformation determine the biological activity of a peptide, as demonstrated by comparative investigations of the inhibition of cholate uptake in liver cells by somatostatin, antamanide, cyclolinopeptide A and 1 and 2. The crystal structure of 1 is the same as that of 2 over a wide range and both react strongly cytoprotectively. (Figure Presented.)

UR - https://www.scopus.com/pages/publications/0022809930

U2 - 10.1002/anie.198609971

DO - 10.1002/anie.198609971

M3 - Article

AN - SCOPUS:0022809930

SN - 0570-0833

VL - 25

SP - 997

EP - 999

JO - Angewandte Chemie International Edition in English

JF - Angewandte Chemie International Edition in English

IS - 11

ER -

Conformational Prerequisites for the in vitro Inhibition of Cholate Uptake in Hepatocytes by Cyclic Analogues of Antamanide and Somatostatin

Abstract

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