Conformational flexibility of the MHC Class I α₁- α₂ domain in peptide bound and free states: A molecular dynamics simulation study

Keyphrases

• C-terminus 100%
• I(1) 100%
• MHC Class II 100%
• Bound States 100%
• Conformational Flexibility 100%
• MHC Class I 100%
• Free State 100%
• Molecular Dynamics Simulation Study 100%
• Chaperone Proteins 66%
• Helix 66%
• N-terminus 66%
• Peptide Binding 66%
• Conformational Dynamics 66%
• Peptide Loading 66%
• Peptide-binding Domains 66%
• Spectroscopic Data 33%
• Binding Region 33%
• Simulation Study 33%
• Molecular Dynamics Simulation 33%
• Protein Chain 33%
• Host Immune Response 33%
• Antigenic Peptide 33%
• Peptide Antigen 33%
• Conformational Change 33%
• Peptide Ligand 33%
• Conformational Fluctuations 33%
• Loading Method 33%
• Binding Cleft 33%
• Proteolytic Digestion 33%
• Conformational Stabilization 33%
• Tapasin 33%
• Empty Form 33%
• Anchor Region 33%

Biochemistry, Genetics and Molecular Biology

• Major Histocompatibility Complex 100%
• MHC Class I 100%
• C-Terminus 100%
• Dynamics 66%
• Chaperone (Protein) 66%
• N-Terminus 66%
• Conformation 66%
• Binding Domain 66%
• Crystal Structure 33%
• Protein Catabolism 33%
• Conformational Change 33%
• Tapasin 33%