Concise classification of the genomic porcine endogenous retroviral γ1 load to defined lineages

Nikolai Klymiuk, Eckhard Wolf, Bernhard Aigner

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


We investigated the infection history of porcine endogenous retroviruses (PERV) γ1 by analyzing published env and LTR sequences. PERV sequences from various breeds, porcine cell lines and infected human primary cells were included in the study. We identified a considerable number of retroviral lineages indicating multiple independent colonization events of the porcine genome. A recent boost of the proviral load in an isolated pig herd and exclusive occurrence of distinct lineages in single studies indicated the ongoing colonization of the porcine genome with endogenous retroviruses. Retroviral recombination between co-packaged genomes was a general factor for PERV γ1 diversity which indicated the simultaneous expression of different proviral loci over a period of time. In total, our detailed description of endogenous retroviral lineages is the prerequisite for breeding approaches to minimize the infectious potential of porcine tissues for the subsequent use in xenotransplantation.

Original languageEnglish
Pages (from-to)175-184
Number of pages10
Issue number1
StatePublished - 5 Feb 2008
Externally publishedYes


  • ERV
  • Evolution
  • PERV
  • Xenotransplantation


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