Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’

Benedikt C. Westphalen; Carsten Bokemeyer; Reinhard Büttner; Stefan Fröhling; Verena I. Gaidzik; Hanno Glimm; Ulrich T. Hacker; Volker Heinemann; Anna L. Illert; Ulrich Keilholz; Thomas Kindler; Martin Kirschner; Bastian Schilling; Jens T. Siveke; Thomas Schroeder; Verena Tischler; Sebastian Wagner; Wilko Weichert; Daniel Zips; Sonja Loges; Ralf Bargou (Würzburg); Hendrik Bläker (Leipzig); Melanie Börries (Freiburg); Christian Brandts (Frankfurt); Melanie Demes (Frankfurt); Alexander Desuki (Mainz); Hartmut Döhner (Ulm); Justus Duyster (Freiburg); Nadine Gaisa (Aachen); Annkristin Heine (Bonn); Christoph Heining (Dresden); Peter Horak (Heidelberg); Ivan Jelas (Berlin); Philipp J. Jost (München); Andreas Jung (München); Thomas Kirchner (München); Frederick Klauschen (Berlin); Simon Kreutzfeldt (Heidelberg); Jörg Kumbrink (München); Volker Kunzmann (Würzburg); Silke Lassmann (Freiburg); Klaus Metzeler (München); Peter Möller (Ulm); Nadina Ortiz-Brüchle (Aachen); Claudia Paret (Mainz); Natalie Pelusi (Bonn); Christoph Peters (Freiburg); Nicole Pfarr (München); Daniela Richter (Dresden); Kristina Riedmann (München); Damian Rieke (Berlin); Christoph Ritzel (Mainz); Dirk Schadendorf (Essen); Hans Ulrich Schildhaus (Essen); Hubert Schorle (Bonn); Thomas Seufferlein (Ulm); Ronald Simon (Hamburg); Albrecht Stenzinger (Heidelberg); Ghazaleh Tabatabai (Tübingen); Janna Lisa Velthaus (Hamburg); Martin Werner (Freiburg); Peter J. Wild (Frankfurt); Jürgen Wolf (Köln)

doi:10.1016/j.ejca.2020.04.019

Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’

Benedikt C. Westphalen
, Carsten Bokemeyer
, Reinhard Büttner
, Stefan Fröhling
, Verena I. Gaidzik
, Hanno Glimm
, Ulrich T. Hacker
, Volker Heinemann
, Anna L. Illert
, Ulrich Keilholz
, Thomas Kindler
, Martin Kirschner
, Bastian Schilling
, Jens T. Siveke
, Thomas Schroeder
, Verena Tischler
, Sebastian Wagner
, Wilko Weichert
, Daniel Zips
, Sonja Loges

Ralf Bargou (Würzburg), Hendrik Bläker (Leipzig), Melanie Börries (Freiburg), Christian Brandts (Frankfurt), Melanie Demes (Frankfurt), Alexander Desuki (Mainz), Hartmut Döhner (Ulm), Justus Duyster (Freiburg), Nadine Gaisa (Aachen), Annkristin Heine (Bonn), Christoph Heining (Dresden), Peter Horak (Heidelberg), Ivan Jelas (Berlin), Philipp J. Jost (München), Andreas Jung (München), Thomas Kirchner (München), Frederick Klauschen (Berlin), Simon Kreutzfeldt (Heidelberg), Jörg Kumbrink (München), Volker Kunzmann (Würzburg), Silke Lassmann (Freiburg), Klaus Metzeler (München), Peter Möller (Ulm), Nadina Ortiz-Brüchle (Aachen), Claudia Paret (Mainz), Natalie Pelusi (Bonn), Christoph Peters (Freiburg), Nicole Pfarr (München), Daniela Richter (Dresden), Kristina Riedmann (München), Damian Rieke (Berlin), Christoph Ritzel (Mainz), Dirk Schadendorf (Essen), Hans Ulrich Schildhaus (Essen), Hubert Schorle (Bonn), Thomas Seufferlein (Ulm), Ronald Simon (Hamburg), Albrecht Stenzinger (Heidelberg), Ghazaleh Tabatabai (Tübingen), Janna Lisa Velthaus (Hamburg), Martin Werner (Freiburg), Peter J. Wild (Frankfurt), Jürgen Wolf (Köln)

Chair of Pathology

Ludwig-Maximilians-Universität München
Universitätsklinikum Hamburg-Eppendorf
Uniklinikum Köln
Network Genomic Medicine
German Cancer Research Center
University Medical Center Ulm and Center of Excellence 'Metabolic Disorders'
National Center for Tumor Diseases (NCT/UCC) Dresden
University of Leipzig
Albert-Ludwigs-Universität Freiburg
Charité – Universitätsmedizin Berlin
University Medical Center
RWTH Aachen University
University Hospital Würzburg
University Hospital of Essen
Heinrich-Heine-University
University of Bonn and University Hospital Bonn
Klinikum der J. W. Goethe-Universität
Comprehensive Cancer Center Tübingen-Stuttgart

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Precision cancer medicine (PCM) holds great promises to offer more effective therapies to patients based on molecular profiling of their individual tumours. Although the PCM approach seems intuitive, multiple conceptional and structural challenges interfere with the broad implementation of PCM into clinical practice. Accordingly, concerted national and international efforts are needed to guide the further development and broad adoption of PCM in Germany. With support of the ‘German Cancer Aid’ (Deutsche Krebshilfe [DKH]) a task force ‘Molecular Diagnostics and Therapy’ was implemented. In two workshops supported by the DKH, delegates from the fourteen comprehensive cancer centresidentified key topics essential to implement quality-guided, harmonized and adaptable PCM. Based on an online questionnaire and using a modified Delphi approach, nine statements were drafted and evaluated within the group. These statements could serve as a basis to define a collaborative strategy for PCM in the future with the aim to sustain and further improve its quality.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	European Journal of Cancer
Volume	135
DOIs	https://doi.org/10.1016/j.ejca.2020.04.019
State	Published - Aug 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Genomic profiling
Molecular diagnostics
Molecular tumour board
Precision medicine
Precision oncology

Access to Document

10.1016/j.ejca.2020.04.019

Cite this

Westphalen, B. C., Bokemeyer, C., Büttner, R., Fröhling, S., Gaidzik, V. I., Glimm, H., Hacker, U. T., Heinemann, V., Illert, A. L., Keilholz, U., Kindler, T., Kirschner, M., Schilling, B., Siveke, J. T., Schroeder, T., Tischler, V., Wagner, S., Weichert, W., Zips, D., ... Wolf (Köln), J. (2020). Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’. European Journal of Cancer, 135, 1-7. https://doi.org/10.1016/j.ejca.2020.04.019

@article{4c00724be29f49fda1a4f9a82248e9a9,

title = "Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group {\textquoteleft}Molecular Diagnostics and Therapy{\textquoteright}",

abstract = "Precision cancer medicine (PCM) holds great promises to offer more effective therapies to patients based on molecular profiling of their individual tumours. Although the PCM approach seems intuitive, multiple conceptional and structural challenges interfere with the broad implementation of PCM into clinical practice. Accordingly, concerted national and international efforts are needed to guide the further development and broad adoption of PCM in Germany. With support of the {\textquoteleft}German Cancer Aid{\textquoteright} (Deutsche Krebshilfe [DKH]) a task force {\textquoteleft}Molecular Diagnostics and Therapy{\textquoteright} was implemented. In two workshops supported by the DKH, delegates from the fourteen comprehensive cancer centresidentified key topics essential to implement quality-guided, harmonized and adaptable PCM. Based on an online questionnaire and using a modified Delphi approach, nine statements were drafted and evaluated within the group. These statements could serve as a basis to define a collaborative strategy for PCM in the future with the aim to sustain and further improve its quality.",

keywords = "Genomic profiling, Molecular diagnostics, Molecular tumour board, Precision medicine, Precision oncology",

author = "Westphalen, \{Benedikt C.\} and Carsten Bokemeyer and Reinhard B{\"u}ttner and Stefan Fr{\"o}hling and Gaidzik, \{Verena I.\} and Hanno Glimm and Hacker, \{Ulrich T.\} and Volker Heinemann and Illert, \{Anna L.\} and Ulrich Keilholz and Thomas Kindler and Martin Kirschner and Bastian Schilling and Siveke, \{Jens T.\} and Thomas Schroeder and Verena Tischler and Sebastian Wagner and Wilko Weichert and Daniel Zips and Sonja Loges and \{Bargou (W{\"u}rzburg)\}, Ralf and \{Bl{\"a}ker (Leipzig)\}, Hendrik and \{B{\"o}rries (Freiburg)\}, Melanie and \{Brandts (Frankfurt)\}, Christian and \{Demes (Frankfurt)\}, Melanie and \{Desuki (Mainz)\}, Alexander and \{D{\"o}hner (Ulm)\}, Hartmut and \{Duyster (Freiburg)\}, Justus and \{Gaisa (Aachen)\}, Nadine and \{Heine (Bonn)\}, Annkristin and \{Heining (Dresden)\}, Christoph and \{Horak (Heidelberg)\}, Peter and \{Jelas (Berlin)\}, Ivan and \{Jost (M{\"u}nchen)\}, \{Philipp J.\} and \{Jung (M{\"u}nchen)\}, Andreas and \{Kirchner (M{\"u}nchen)\}, Thomas and \{Klauschen (Berlin)\}, Frederick and \{Kreutzfeldt (Heidelberg)\}, Simon and \{Kumbrink (M{\"u}nchen)\}, J{\"o}rg and \{Kunzmann (W{\"u}rzburg)\}, Volker and \{Lassmann (Freiburg)\}, Silke and \{Metzeler (M{\"u}nchen)\}, Klaus and \{M{\"o}ller (Ulm)\}, Peter and \{Ortiz-Br{\"u}chle (Aachen)\}, Nadina and \{Paret (Mainz)\}, Claudia and \{Pelusi (Bonn)\}, Natalie and \{Peters (Freiburg)\}, Christoph and \{Pfarr (M{\"u}nchen)\}, Nicole and \{Richter (Dresden)\}, Daniela and \{Riedmann (M{\"u}nchen)\}, Kristina and \{Rieke (Berlin)\}, Damian and \{Ritzel (Mainz)\}, Christoph and \{Schadendorf (Essen)\}, Dirk and \{Schildhaus (Essen)\}, \{Hans Ulrich\} and \{Schorle (Bonn)\}, Hubert and \{Seufferlein (Ulm)\}, Thomas and \{Simon (Hamburg)\}, Ronald and \{Stenzinger (Heidelberg)\}, Albrecht and \{Tabatabai (T{\"u}bingen)\}, Ghazaleh and \{Velthaus (Hamburg)\}, \{Janna Lisa\} and \{Werner (Freiburg)\}, Martin and \{Wild (Frankfurt)\}, \{Peter J.\} and \{Wolf (K{\"o}ln)\}, J{\"u}rgen",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = aug,

doi = "10.1016/j.ejca.2020.04.019",

language = "English",

volume = "135",

pages = "1--7",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Ltd.",

}

Westphalen, BC, Bokemeyer, C, Büttner, R, Fröhling, S, Gaidzik, VI, Glimm, H, Hacker, UT, Heinemann, V, Illert, AL, Keilholz, U, Kindler, T, Kirschner, M, Schilling, B, Siveke, JT, Schroeder, T, Tischler, V, Wagner, S, Weichert, W, Zips, D, Loges, S, Bargou (Würzburg), R, Bläker (Leipzig), H, Börries (Freiburg), M, Brandts (Frankfurt), C, Demes (Frankfurt), M, Desuki (Mainz), A, Döhner (Ulm), H, Duyster (Freiburg), J, Gaisa (Aachen), N, Heine (Bonn), A, Heining (Dresden), C, Horak (Heidelberg), P, Jelas (Berlin), I, Jost (München), PJ, Jung (München), A, Kirchner (München), T, Klauschen (Berlin), F, Kreutzfeldt (Heidelberg), S, Kumbrink (München), J, Kunzmann (Würzburg), V, Lassmann (Freiburg), S, Metzeler (München), K, Möller (Ulm), P, Ortiz-Brüchle (Aachen), N, Paret (Mainz), C, Pelusi (Bonn), N, Peters (Freiburg), C, Pfarr (München), N, Richter (Dresden), D, Riedmann (München), K, Rieke (Berlin), D, Ritzel (Mainz), C, Schadendorf (Essen), D, Schildhaus (Essen), HU, Schorle (Bonn), H, Seufferlein (Ulm), T, Simon (Hamburg), R, Stenzinger (Heidelberg), A, Tabatabai (Tübingen), G, Velthaus (Hamburg), JL, Werner (Freiburg), M, Wild (Frankfurt), PJ & Wolf (Köln), J 2020, 'Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’', European Journal of Cancer, vol. 135, pp. 1-7. https://doi.org/10.1016/j.ejca.2020.04.019

Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’. / Westphalen, Benedikt C.; Bokemeyer, Carsten; Büttner, Reinhard et al.
In: European Journal of Cancer, Vol. 135, 08.2020, p. 1-7.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Conceptual framework for precision cancer medicine in Germany

T2 - Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’

AU - Westphalen, Benedikt C.

AU - Bokemeyer, Carsten

AU - Büttner, Reinhard

AU - Fröhling, Stefan

AU - Gaidzik, Verena I.

AU - Glimm, Hanno

AU - Hacker, Ulrich T.

AU - Heinemann, Volker

AU - Illert, Anna L.

AU - Keilholz, Ulrich

AU - Kindler, Thomas

AU - Kirschner, Martin

AU - Schilling, Bastian

AU - Siveke, Jens T.

AU - Schroeder, Thomas

AU - Tischler, Verena

AU - Wagner, Sebastian

AU - Weichert, Wilko

AU - Zips, Daniel

AU - Loges, Sonja

AU - Bargou (Würzburg), Ralf

AU - Bläker (Leipzig), Hendrik

AU - Börries (Freiburg), Melanie

AU - Brandts (Frankfurt), Christian

AU - Demes (Frankfurt), Melanie

AU - Desuki (Mainz), Alexander

AU - Döhner (Ulm), Hartmut

AU - Duyster (Freiburg), Justus

AU - Gaisa (Aachen), Nadine

AU - Heine (Bonn), Annkristin

AU - Heining (Dresden), Christoph

AU - Horak (Heidelberg), Peter

AU - Jelas (Berlin), Ivan

AU - Jost (München), Philipp J.

AU - Jung (München), Andreas

AU - Kirchner (München), Thomas

AU - Klauschen (Berlin), Frederick

AU - Kreutzfeldt (Heidelberg), Simon

AU - Kumbrink (München), Jörg

AU - Kunzmann (Würzburg), Volker

AU - Lassmann (Freiburg), Silke

AU - Metzeler (München), Klaus

AU - Möller (Ulm), Peter

AU - Ortiz-Brüchle (Aachen), Nadina

AU - Paret (Mainz), Claudia

AU - Pelusi (Bonn), Natalie

AU - Peters (Freiburg), Christoph

AU - Pfarr (München), Nicole

AU - Richter (Dresden), Daniela

AU - Riedmann (München), Kristina

AU - Rieke (Berlin), Damian

AU - Ritzel (Mainz), Christoph

AU - Schadendorf (Essen), Dirk

AU - Schildhaus (Essen), Hans Ulrich

AU - Schorle (Bonn), Hubert

AU - Seufferlein (Ulm), Thomas

AU - Simon (Hamburg), Ronald

AU - Stenzinger (Heidelberg), Albrecht

AU - Tabatabai (Tübingen), Ghazaleh

AU - Velthaus (Hamburg), Janna Lisa

AU - Werner (Freiburg), Martin

AU - Wild (Frankfurt), Peter J.

AU - Wolf (Köln), Jürgen

PY - 2020/8

Y1 - 2020/8

N2 - Precision cancer medicine (PCM) holds great promises to offer more effective therapies to patients based on molecular profiling of their individual tumours. Although the PCM approach seems intuitive, multiple conceptional and structural challenges interfere with the broad implementation of PCM into clinical practice. Accordingly, concerted national and international efforts are needed to guide the further development and broad adoption of PCM in Germany. With support of the ‘German Cancer Aid’ (Deutsche Krebshilfe [DKH]) a task force ‘Molecular Diagnostics and Therapy’ was implemented. In two workshops supported by the DKH, delegates from the fourteen comprehensive cancer centresidentified key topics essential to implement quality-guided, harmonized and adaptable PCM. Based on an online questionnaire and using a modified Delphi approach, nine statements were drafted and evaluated within the group. These statements could serve as a basis to define a collaborative strategy for PCM in the future with the aim to sustain and further improve its quality.

AB - Precision cancer medicine (PCM) holds great promises to offer more effective therapies to patients based on molecular profiling of their individual tumours. Although the PCM approach seems intuitive, multiple conceptional and structural challenges interfere with the broad implementation of PCM into clinical practice. Accordingly, concerted national and international efforts are needed to guide the further development and broad adoption of PCM in Germany. With support of the ‘German Cancer Aid’ (Deutsche Krebshilfe [DKH]) a task force ‘Molecular Diagnostics and Therapy’ was implemented. In two workshops supported by the DKH, delegates from the fourteen comprehensive cancer centresidentified key topics essential to implement quality-guided, harmonized and adaptable PCM. Based on an online questionnaire and using a modified Delphi approach, nine statements were drafted and evaluated within the group. These statements could serve as a basis to define a collaborative strategy for PCM in the future with the aim to sustain and further improve its quality.

KW - Genomic profiling

KW - Molecular diagnostics

KW - Molecular tumour board

KW - Precision medicine

KW - Precision oncology

UR - https://www.scopus.com/pages/publications/85086016989

U2 - 10.1016/j.ejca.2020.04.019

DO - 10.1016/j.ejca.2020.04.019

M3 - Review article

C2 - 32521293

AN - SCOPUS:85086016989

SN - 0959-8049

VL - 135

SP - 1

EP - 7

JO - European Journal of Cancer

JF - European Journal of Cancer

ER -

Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’

Abstract

UN SDGs

Keywords

Access to Document

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