Concepts in oncolytic adenovirus therapy

Klaus Mantwill, Florian Gerhard Klein, Dongbiao Wang, Sruthi Vasantamadhava Hindupur, Maximilian Ehrenfeld, Per Sonne Holm, Roman Nawroth

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Oncolytic adenovirus therapy is gaining importance as a novel treatment option for the management of various cancers. Different concepts of modification within the adenovirus vector have been identified that define the mode of action against and the interaction with the tumour. Adenoviral vectors allow for genetic manipulations that restrict tumour specificity and also the expression of specific transgenes in order to support the anti-tumour effect. Additionally, replication of the virus and reinfection of neighbouring tumour cells amplify the therapeutic effect. Another important aspect in oncolytic adenovirus therapy is the virus induced cell death which is a process that activates the immune system against the tumour. This review describes which elements in adenovirus vectors have been identified for modification not only to utilize oncolytic adenovirus vectors into conditionally replicating adenoviruses (CRAds) that allow replication specifically in tumour cells but also to confer specific characteristics to these viruses. These advances in development resulted in clinical trials that are summarized based on the conceptual design.

Original languageEnglish
Article number10522
JournalInternational Journal of Molecular Sciences
Volume22
Issue number19
DOIs
StatePublished - 1 Oct 2021
Externally publishedYes

Keywords

  • Adenovirus
  • Arming
  • CRAd
  • Cancer
  • Immunotherapy
  • Oncolytic virus
  • Tropism
  • Vector design

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