Abstract
This paper presents a concept for an implantable micro-pump based on hydrogen- generating gas cells. The gas-generating cell is separated from the drug reservoir by an expandable latex membrane. The system offers linear drug delivery with flowrates ranging from 8-nl/s to 2-μl/s and a total delivery volume of up to 160-ml. Drugs can be dispensed over a wide backpressure range. The device is scalable based on the size of the gas-producing cell and requires no external energy source. Possible fields of application include in vivo local drug delivery for chemotherapy, diabetes, and pain management.
| Original language | English |
|---|---|
| Pages (from-to) | 1196-1201 |
| Number of pages | 6 |
| Journal | Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine |
| Volume | 225 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2011 |
Keywords
- drug delivery device
- gas cell
- implantable pump
