Computerized analysis of enhancement kinetics for preoperative lymph node staging in rectal cancer using dynamic contrast-enhanced magnetic resonance imaging

Tibor Vag, Julia Slotta-Huspenina, Robert Rosenberg, Franz G. Bader, Ulrich Nitsche, Enken Drecoll, Ernst J. Rummeny, Jochen Gaa

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

For this feasibility study, dynamic contrast-enhanced magnetic resonance imaging (dceMRI) was performed preoperatively in 9 patients with histologically proven rectal carcinoma. A total of 41 lymph nodes detected were matched to histopathology. Their contrast enhancement patterns were evaluated using computer-aided analysis and categorized in persistent, plateau, and washout curve type. Highest diagnostic accuracy for detecting malignancy was observed, when less than 31.8% of the voxels within a lymph node demonstrated a washout curve (sensitivity/specificity of 81.8%/89.7%; area under the curve, AUC=0.87). In comparison, conventional size measurements revealed lower AUC of 0.81 (sensitivity/specificity of 75%/72.4%). We conclude that dceMRI might be of diagnostic value for preoperative lymph node staging.

Original languageEnglish
Pages (from-to)845-849
Number of pages5
JournalClinical Imaging
Volume38
Issue number6
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • CAD
  • Enhancement kinetics
  • Lymph node
  • MRI
  • Rectal cancer

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