TY - JOUR
T1 - Computation of an MRI brain atlas from a population of Parkinson's disease patients
AU - Angelidakis, L.
AU - Papageorgiou, I. E.
AU - Damianou, C.
AU - Psychogios, M. N.
AU - Lingor, P.
AU - Von Eckardstein, K.
AU - Hadjidemetriou, S.
N1 - Publisher Copyright:
© Published under licence by IOP Publishing Ltd.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Parkinson's Disease (PD) is a degenerative disorder of the brain. This study presents an MRI-based brain atlas of PD to characterize associated alterations for diagnostic and interventional purposes. The atlas standardizes primarily the implicated subcortical regions such as the globus pallidus (GP), substantia nigra (SN), subthalamic nucleus (STN), caudate nucleus (CN), thalamus (TH), putamen (PUT), and red nucleus (RN). The data were 3.0 T MRI brain images from 16 PD patients and 10 matched controls. The images used were T1-weighted (T 1 w), T2-weighted (T 2 w) images, and Susceptibility Weighted Images (SWI). The T1w images were the reference for the inter-subject non-rigid registration available from 3DSlicer. Anatomic labeling was achieved with BrainSuite and regions were refined with the level sets segmentation of ITK-Snap. The subcortical centers were analyzed for their volume and signal intensity. Comparison with an age-matched control group unravels a significant PD-related T1w signal loss in the striatum (CN and PUT) centers, but approximately a constant volume. The results in this study improve MRI based PD localization and can lead to the development of novel biomarkers.
AB - Parkinson's Disease (PD) is a degenerative disorder of the brain. This study presents an MRI-based brain atlas of PD to characterize associated alterations for diagnostic and interventional purposes. The atlas standardizes primarily the implicated subcortical regions such as the globus pallidus (GP), substantia nigra (SN), subthalamic nucleus (STN), caudate nucleus (CN), thalamus (TH), putamen (PUT), and red nucleus (RN). The data were 3.0 T MRI brain images from 16 PD patients and 10 matched controls. The images used were T1-weighted (T 1 w), T2-weighted (T 2 w) images, and Susceptibility Weighted Images (SWI). The T1w images were the reference for the inter-subject non-rigid registration available from 3DSlicer. Anatomic labeling was achieved with BrainSuite and regions were refined with the level sets segmentation of ITK-Snap. The subcortical centers were analyzed for their volume and signal intensity. Comparison with an age-matched control group unravels a significant PD-related T1w signal loss in the striatum (CN and PUT) centers, but approximately a constant volume. The results in this study improve MRI based PD localization and can lead to the development of novel biomarkers.
KW - 3DSlicer
KW - Brain 3 Tesla MRI atlas
KW - Parkinsońs disease biomarkers
KW - SWI
KW - basal ganglia
KW - neurodegeneration.
KW - striatum
UR - http://www.scopus.com/inward/record.url?scp=85039455254&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/931/1/012006
DO - 10.1088/1742-6596/931/1/012006
M3 - Conference article
AN - SCOPUS:85039455254
SN - 1742-6588
VL - 931
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
IS - 1
M1 - 012006
T2 - International Conference on Bio-Medical Instrumentation and Related Engineering and Physical Sciences 2017, BIOMEP 2017
Y2 - 12 October 2017 through 13 October 2017
ER -