TY - JOUR
T1 - Compromised gut microbiota networks in children with anti-islet cell autoimmunity
AU - Endesfelder, David
AU - Castell, Wolfgang Zu
AU - Ardissone, Alexandria
AU - Davis-Richardson, Austin G.
AU - Achenbach, Peter
AU - Hagen, Michael
AU - Pflueger, Maren
AU - Gano, Kelsey A.
AU - Fagen, Jennie R.
AU - Drew, Jennifer C.
AU - Brown, Christopher T.
AU - Kolaczkowski, Bryan
AU - Atkinson, Mark
AU - Schatz, Desmond
AU - Bonifacio, Ezio
AU - Triplett, Eric W.
AU - Ziegler, Anette G.
PY - 2014/6
Y1 - 2014/6
N2 - The gut microbiome is suggested to play a role in the pathogenesis of autoimmune disorders such as type 1 diabetes. Evidence of anti-islet cell autoimmunity in type 1 diabetes appears in the first years of life; however, little is known regarding the establishment of the gut microbiome in early infancy. Here, we sought to determine whether differences were present in early composition of the gut microbiome in children in whom anti-islet cell autoimmunity developed. We investigated the microbiome of 298 stool samples prospectively taken up to age 3 years from 22 case children in whom anti-islet cell autoantibodies developed, and 22 matched control children who remained islet cell autoantibody+ negative in follow-up. The microbiome changed markedly during the first year of life, and was further affected by breast-feeding, food introduction, and birth delivery mode. No differences between anti-islet cell autoantibody+positive and +negative children were found in bacterial diversity, microbial composition, or singlegenus abundances. However, substantial alterations in microbial interaction networks were observed at age 0.5 and 2 years in the children in whom anti-islet cell autoantibodies developed. The findings underscore a role of the microbiome in the pathogenesis of anti-islet cell autoimmunity and type 1 diabetes.
AB - The gut microbiome is suggested to play a role in the pathogenesis of autoimmune disorders such as type 1 diabetes. Evidence of anti-islet cell autoimmunity in type 1 diabetes appears in the first years of life; however, little is known regarding the establishment of the gut microbiome in early infancy. Here, we sought to determine whether differences were present in early composition of the gut microbiome in children in whom anti-islet cell autoimmunity developed. We investigated the microbiome of 298 stool samples prospectively taken up to age 3 years from 22 case children in whom anti-islet cell autoantibodies developed, and 22 matched control children who remained islet cell autoantibody+ negative in follow-up. The microbiome changed markedly during the first year of life, and was further affected by breast-feeding, food introduction, and birth delivery mode. No differences between anti-islet cell autoantibody+positive and +negative children were found in bacterial diversity, microbial composition, or singlegenus abundances. However, substantial alterations in microbial interaction networks were observed at age 0.5 and 2 years in the children in whom anti-islet cell autoantibodies developed. The findings underscore a role of the microbiome in the pathogenesis of anti-islet cell autoimmunity and type 1 diabetes.
UR - http://www.scopus.com/inward/record.url?scp=84901330157&partnerID=8YFLogxK
U2 - 10.2337/db13-1676
DO - 10.2337/db13-1676
M3 - Article
C2 - 24608442
AN - SCOPUS:84901330157
SN - 0012-1797
VL - 63
SP - 2006
EP - 2014
JO - Diabetes
JF - Diabetes
IS - 6
ER -