Complementary metal oxide semiconductor compatible silicon nanowires-on-a-chip: Fabrication and preclinical validation for the detection of a cancer prognostic protein marker in serum

Duy P. Tran; Bernhard Wolfrum; Regina Stockmann; Jing Hong Pai; Mohammad Pourhassan-Moghaddam; Andreas Offenhäusser; Benjamin Thierry

doi:10.1021/ac503374j

Complementary metal oxide semiconductor compatible silicon nanowires-on-a-chip: Fabrication and preclinical validation for the detection of a cancer prognostic protein marker in serum

Duy P. Tran, Bernhard Wolfrum, Regina Stockmann, Jing Hong Pai, Mohammad Pourhassan-Moghaddam, Andreas Offenhäusser, Benjamin Thierry

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

An integrated translational biosensing technology based on arrays of silicon nanowire field-effect transistors (SiNW FETs) is described and has been preclinically validated for the ultrasensitive detection of the cancer biomarker ALCAM in serum. High-quality SiNW arrays have been rationally designed toward their implementation as molecular biosensors. The FET sensing platform has been fabricated using a complementary metal oxide semiconductor (CMOS)-compatible process. Reliable and reproducible electrical performance has been demonstrated via electrical characterization using a custom-designed portable readout device. Using this platform, the cancer prognostic marker ALCAM could be detected in serum with a detection limit of 15.5 pg/mL. Importantly, the detection could be completed in less than 30 min and span a wide dynamic detection range (∼10⁵). The SiNW-on-a-chip biosensing technology paves the way to the translational clinical application of FET in the detection of cancer protein markers.

Original language	English
Pages (from-to)	1662-1668
Number of pages	7
Journal	Analytical Chemistry
Volume	87
Issue number	3
DOIs	https://doi.org/10.1021/ac503374j
State	Published - 3 Feb 2015
Externally published	Yes

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Tran, D. P., Wolfrum, B., Stockmann, R., Pai, J. H., Pourhassan-Moghaddam, M., Offenhäusser, A., & Thierry, B. (2015). Complementary metal oxide semiconductor compatible silicon nanowires-on-a-chip: Fabrication and preclinical validation for the detection of a cancer prognostic protein marker in serum. Analytical Chemistry, 87(3), 1662-1668. https://doi.org/10.1021/ac503374j

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title = "Complementary metal oxide semiconductor compatible silicon nanowires-on-a-chip: Fabrication and preclinical validation for the detection of a cancer prognostic protein marker in serum",

abstract = "An integrated translational biosensing technology based on arrays of silicon nanowire field-effect transistors (SiNW FETs) is described and has been preclinically validated for the ultrasensitive detection of the cancer biomarker ALCAM in serum. High-quality SiNW arrays have been rationally designed toward their implementation as molecular biosensors. The FET sensing platform has been fabricated using a complementary metal oxide semiconductor (CMOS)-compatible process. Reliable and reproducible electrical performance has been demonstrated via electrical characterization using a custom-designed portable readout device. Using this platform, the cancer prognostic marker ALCAM could be detected in serum with a detection limit of 15.5 pg/mL. Importantly, the detection could be completed in less than 30 min and span a wide dynamic detection range (∼105). The SiNW-on-a-chip biosensing technology paves the way to the translational clinical application of FET in the detection of cancer protein markers.",

author = "Tran, {Duy P.} and Bernhard Wolfrum and Regina Stockmann and Pai, {Jing Hong} and Mohammad Pourhassan-Moghaddam and Andreas Offenh{\"a}usser and Benjamin Thierry",

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Tran, DP, Wolfrum, B, Stockmann, R, Pai, JH, Pourhassan-Moghaddam, M, Offenhäusser, A & Thierry, B 2015, 'Complementary metal oxide semiconductor compatible silicon nanowires-on-a-chip: Fabrication and preclinical validation for the detection of a cancer prognostic protein marker in serum', Analytical Chemistry, vol. 87, no. 3, pp. 1662-1668. https://doi.org/10.1021/ac503374j

Complementary metal oxide semiconductor compatible silicon nanowires-on-a-chip: Fabrication and preclinical validation for the detection of a cancer prognostic protein marker in serum. / Tran, Duy P.; Wolfrum, Bernhard; Stockmann, Regina et al.
In: Analytical Chemistry, Vol. 87, No. 3, 03.02.2015, p. 1662-1668.

Research output: Contribution to journal › Article › peer-review

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AU - Tran, Duy P.

AU - Wolfrum, Bernhard

AU - Stockmann, Regina

AU - Pai, Jing Hong

AU - Pourhassan-Moghaddam, Mohammad

AU - Offenhäusser, Andreas

AU - Thierry, Benjamin

PY - 2015/2/3

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N2 - An integrated translational biosensing technology based on arrays of silicon nanowire field-effect transistors (SiNW FETs) is described and has been preclinically validated for the ultrasensitive detection of the cancer biomarker ALCAM in serum. High-quality SiNW arrays have been rationally designed toward their implementation as molecular biosensors. The FET sensing platform has been fabricated using a complementary metal oxide semiconductor (CMOS)-compatible process. Reliable and reproducible electrical performance has been demonstrated via electrical characterization using a custom-designed portable readout device. Using this platform, the cancer prognostic marker ALCAM could be detected in serum with a detection limit of 15.5 pg/mL. Importantly, the detection could be completed in less than 30 min and span a wide dynamic detection range (∼105). The SiNW-on-a-chip biosensing technology paves the way to the translational clinical application of FET in the detection of cancer protein markers.

AB - An integrated translational biosensing technology based on arrays of silicon nanowire field-effect transistors (SiNW FETs) is described and has been preclinically validated for the ultrasensitive detection of the cancer biomarker ALCAM in serum. High-quality SiNW arrays have been rationally designed toward their implementation as molecular biosensors. The FET sensing platform has been fabricated using a complementary metal oxide semiconductor (CMOS)-compatible process. Reliable and reproducible electrical performance has been demonstrated via electrical characterization using a custom-designed portable readout device. Using this platform, the cancer prognostic marker ALCAM could be detected in serum with a detection limit of 15.5 pg/mL. Importantly, the detection could be completed in less than 30 min and span a wide dynamic detection range (∼105). The SiNW-on-a-chip biosensing technology paves the way to the translational clinical application of FET in the detection of cancer protein markers.

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Complementary metal oxide semiconductor compatible silicon nanowires-on-a-chip: Fabrication and preclinical validation for the detection of a cancer prognostic protein marker in serum

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