Complementarity of molecular and elemental mass spectrometric imaging of Gadovist in mouse tissues

Sabrina Trog, Ahmed H. El-Khatib, Sebastian Beck, Marcus R. Makowski, Norbert Jakubowski, Michael W. Linscheid

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Drug biodistribution analyses can be considered a key issue in pharmaceutical discovery and development. Here, mass spectrometric imaging can be employed as a powerful tool to investigate distributions of drug compounds in biologically and medically relevant tissue sections. Both matrix-assisted laser desorption ionization–mass spectrometric imaging as molecular method and laser ablation inductively coupled plasma–mass spectrometric imaging as elemental detection method were applied to determine drug distributions in tissue thin sections. Several mouse organs including the heart, kidney, liver, and brain were analyzed with regard to distribution of Gadovist , a gadolinium-based contrast agent already approved for clinical investigation. This work demonstrated the successful detection and localization of Gadovist in several organs. Furthermore, the results gave evidence that gadolinium-based contrast agents in general can be well analyzed by mass spectrometric imaging methods. In conclusion, the combined application of molecular and elemental mass spectrometry could complement each other and thus confirm analytical results or provide additional information.

Original languageEnglish
Pages (from-to)629-637
Number of pages9
JournalAnalytical and Bioanalytical Chemistry
Issue number3
StatePublished - 23 Jan 2019
Externally publishedYes


  • Gadolinium-based contrast agents (GBCAs)
  • Laser ablation inductively coupled plasma–mass spectrometry imaging (LA-ICP-MSI)
  • Matrix-assisted laser desorption ionization–mass spectrometry imaging (MALDI-MSI)


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