TY - JOUR
T1 - Complement and immunoglobulin deposits in the skin of patients with atopic dermatitis
AU - RING, JOHANNES
AU - SENTER, THOMAS
AU - CORNELL, ROGER C.
AU - ARROYAVE, CARLOS M.
AU - TAN, ENG M.
PY - 1978/11
Y1 - 1978/11
N2 - The immunofluorescent patterns of uninvolved and involved skin biopsies from eight patients with atopic dermatitis were studied, using direct immunofluorescence techniques to identify deposits of the immunoglobulins G, A and M as well as the complement factors CIq, C3, C4, C5, factor B and properdin. Immunoglobulin deposits (mainly IgG) were found in five patients, complement deposits in three patients in the basement membrane zone. In three patients the immunofluorescence was positive for C3, in two patients for CIq, C4 and C5. Regarding the factors of the alternative pathway of the complement system, two patients showed deposits of properdin, one of factor B. The changes were not confined to the eczematous lesions, but were found in uninvolved skin too. The most prominent changes were observed in patients with severe disease.
AB - The immunofluorescent patterns of uninvolved and involved skin biopsies from eight patients with atopic dermatitis were studied, using direct immunofluorescence techniques to identify deposits of the immunoglobulins G, A and M as well as the complement factors CIq, C3, C4, C5, factor B and properdin. Immunoglobulin deposits (mainly IgG) were found in five patients, complement deposits in three patients in the basement membrane zone. In three patients the immunofluorescence was positive for C3, in two patients for CIq, C4 and C5. Regarding the factors of the alternative pathway of the complement system, two patients showed deposits of properdin, one of factor B. The changes were not confined to the eczematous lesions, but were found in uninvolved skin too. The most prominent changes were observed in patients with severe disease.
UR - http://www.scopus.com/inward/record.url?scp=0018143002&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2133.1978.tb02016.x
DO - 10.1111/j.1365-2133.1978.tb02016.x
M3 - Article
C2 - 361063
AN - SCOPUS:0018143002
SN - 0007-0963
VL - 99
SP - 495
EP - 501
JO - British Journal of Dermatology
JF - British Journal of Dermatology
IS - 5
ER -