Comparison study of oxygen-induced MRI-signal changes and pO2 changes in murine tumors

Lothar Weissfloch; Michael Peller; Juergen Weber; Hans Juergen Feldmann; Reingart Senekowitsch-Schmidtke; Karlheinz Tempel; Jeffrey A. Coderre; Michael Molls; Michael Reiser

doi:10.1007/978-1-4615-0075-9_43

Comparison study of oxygen-induced MRI-signal changes and pO₂ changes in murine tumors

Lothar Weissfloch
, Michael Peller
, Juergen Weber
, Hans Juergen Feldmann
, Reingart Senekowitsch-Schmidtke
, Karlheinz Tempel
, Jeffrey A. Coderre
, Michael Molls
, Michael Reiser

TUM Institute for Advanced Study

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The purpose of this study was to compare the results from oxygen-induced MR-signal intensity changes with polarographic pO₂ measurements in tumors. Balb-c mice with an intramuscular transplanted osteosarcoma were examined. To study the response of tumors to changes in oxygen supply, hyperoxia was induced by breathing pure oxygen for a short period. The examination of each animal started with T2* weighted MRI followed by the pO₂ measurements (Eppendorf Histograph). During oxygen inhalation in all tumors, when the hypoxic tumor fraction drops, both areas of significant MR-signal intensity increase and decrease were observed in each animal.

Original language	English
Pages (from-to)	461-465
Number of pages	5
Journal	Advances in Experimental Medicine and Biology
Volume	530
DOIs	https://doi.org/10.1007/978-1-4615-0075-9_43
State	Published - 2003

Keywords

Hyperoxia
MRI
Oxygen tension measurement
Rodent
Tumor
pO

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10.1007/978-1-4615-0075-9_43

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title = "Comparison study of oxygen-induced MRI-signal changes and pO2 changes in murine tumors",

abstract = "The purpose of this study was to compare the results from oxygen-induced MR-signal intensity changes with polarographic pO2 measurements in tumors. Balb-c mice with an intramuscular transplanted osteosarcoma were examined. To study the response of tumors to changes in oxygen supply, hyperoxia was induced by breathing pure oxygen for a short period. The examination of each animal started with T2* weighted MRI followed by the pO2 measurements (Eppendorf Histograph). During oxygen inhalation in all tumors, when the hypoxic tumor fraction drops, both areas of significant MR-signal intensity increase and decrease were observed in each animal.",

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author = "Lothar Weissfloch and Michael Peller and Juergen Weber and Feldmann, \{Hans Juergen\} and Reingart Senekowitsch-Schmidtke and Karlheinz Tempel and Coderre, \{Jeffrey A.\} and Michael Molls and Michael Reiser",

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doi = "10.1007/978-1-4615-0075-9\_43",

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T1 - Comparison study of oxygen-induced MRI-signal changes and pO2 changes in murine tumors

AU - Weissfloch, Lothar

AU - Peller, Michael

AU - Weber, Juergen

AU - Feldmann, Hans Juergen

AU - Senekowitsch-Schmidtke, Reingart

AU - Tempel, Karlheinz

AU - Coderre, Jeffrey A.

AU - Molls, Michael

AU - Reiser, Michael

PY - 2003

Y1 - 2003

N2 - The purpose of this study was to compare the results from oxygen-induced MR-signal intensity changes with polarographic pO2 measurements in tumors. Balb-c mice with an intramuscular transplanted osteosarcoma were examined. To study the response of tumors to changes in oxygen supply, hyperoxia was induced by breathing pure oxygen for a short period. The examination of each animal started with T2* weighted MRI followed by the pO2 measurements (Eppendorf Histograph). During oxygen inhalation in all tumors, when the hypoxic tumor fraction drops, both areas of significant MR-signal intensity increase and decrease were observed in each animal.

AB - The purpose of this study was to compare the results from oxygen-induced MR-signal intensity changes with polarographic pO2 measurements in tumors. Balb-c mice with an intramuscular transplanted osteosarcoma were examined. To study the response of tumors to changes in oxygen supply, hyperoxia was induced by breathing pure oxygen for a short period. The examination of each animal started with T2* weighted MRI followed by the pO2 measurements (Eppendorf Histograph). During oxygen inhalation in all tumors, when the hypoxic tumor fraction drops, both areas of significant MR-signal intensity increase and decrease were observed in each animal.

KW - Hyperoxia

KW - MRI

KW - Oxygen tension measurement

KW - Rodent

KW - Tumor

KW - pO

UR - https://www.scopus.com/pages/publications/0242362064

U2 - 10.1007/978-1-4615-0075-9_43

DO - 10.1007/978-1-4615-0075-9_43

M3 - Article

C2 - 14562741

AN - SCOPUS:0242362064

SN - 0065-2598

VL - 530

SP - 461

EP - 465

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

ER -

Comparison study of oxygen-induced MRI-signal changes and pO₂ changes in murine tumors

Abstract

Keywords

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