TY - JOUR
T1 - Comparison study of oxygen-induced MRI-signal changes and pO2 changes in murine tumors
AU - Weissfloch, Lothar
AU - Peller, Michael
AU - Weber, Juergen
AU - Feldmann, Hans Juergen
AU - Senekowitsch-Schmidtke, Reingart
AU - Tempel, Karlheinz
AU - Coderre, Jeffrey A.
AU - Molls, Michael
AU - Reiser, Michael
PY - 2003
Y1 - 2003
N2 - The purpose of this study was to compare the results from oxygen-induced MR-signal intensity changes with polarographic pO2 measurements in tumors. Balb-c mice with an intramuscular transplanted osteosarcoma were examined. To study the response of tumors to changes in oxygen supply, hyperoxia was induced by breathing pure oxygen for a short period. The examination of each animal started with T2* weighted MRI followed by the pO2 measurements (Eppendorf Histograph). During oxygen inhalation in all tumors, when the hypoxic tumor fraction drops, both areas of significant MR-signal intensity increase and decrease were observed in each animal.
AB - The purpose of this study was to compare the results from oxygen-induced MR-signal intensity changes with polarographic pO2 measurements in tumors. Balb-c mice with an intramuscular transplanted osteosarcoma were examined. To study the response of tumors to changes in oxygen supply, hyperoxia was induced by breathing pure oxygen for a short period. The examination of each animal started with T2* weighted MRI followed by the pO2 measurements (Eppendorf Histograph). During oxygen inhalation in all tumors, when the hypoxic tumor fraction drops, both areas of significant MR-signal intensity increase and decrease were observed in each animal.
KW - Hyperoxia
KW - MRI
KW - Oxygen tension measurement
KW - Rodent
KW - Tumor
KW - pO
UR - http://www.scopus.com/inward/record.url?scp=0242362064&partnerID=8YFLogxK
U2 - 10.1007/978-1-4615-0075-9_43
DO - 10.1007/978-1-4615-0075-9_43
M3 - Article
C2 - 14562741
AN - SCOPUS:0242362064
SN - 0065-2598
VL - 530
SP - 461
EP - 465
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
ER -