Comparison study of oxygen-induced MRI-signal changes and pO2 changes in murine tumors

Lothar Weissfloch, Michael Peller, Juergen Weber, Hans Juergen Feldmann, Reingart Senekowitsch-Schmidtke, Karlheinz Tempel, Jeffrey A. Coderre, Michael Molls, Michael Reiser

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The purpose of this study was to compare the results from oxygen-induced MR-signal intensity changes with polarographic pO2 measurements in tumors. Balb-c mice with an intramuscular transplanted osteosarcoma were examined. To study the response of tumors to changes in oxygen supply, hyperoxia was induced by breathing pure oxygen for a short period. The examination of each animal started with T2* weighted MRI followed by the pO2 measurements (Eppendorf Histograph). During oxygen inhalation in all tumors, when the hypoxic tumor fraction drops, both areas of significant MR-signal intensity increase and decrease were observed in each animal.

Original languageEnglish
Pages (from-to)461-465
Number of pages5
JournalAdvances in Experimental Medicine and Biology
Volume530
DOIs
StatePublished - 2003

Keywords

  • Hyperoxia
  • MRI
  • Oxygen tension measurement
  • Rodent
  • Tumor
  • pO

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