Comparison of sodium nitroprusside versus esmolol for the treatment of hypertension following repair of coarctation of the aorta

Sven Dittrich; Joannis Germanakis; Heike Dittrich; Ingo Daehnert; Peter Ewert; Vladimir Alexi-Meskishvili; Michael Vogel; Peter E. Lange

doi:10.1016/S1569-9293(02)00115-9

Comparison of sodium nitroprusside versus esmolol for the treatment of hypertension following repair of coarctation of the aorta

Sven Dittrich, Joannis Germanakis, Heike Dittrich, Ingo Daehnert, Peter Ewert, Vladimir Alexi-Meskishvili, Michael Vogel, Peter E. Lange

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Postoperative arterial hypertension was treated with nitroprusside or esmolol in a prospective randomized study. If treatment failed, patients were first switched over to the other study drug, and then to a combination of both. Renin, angiotensin II, epinephrine, and norepinephrine were measured before, 1, and 17 h after operation. esmolol was effective in all cases of treatment (n=6) whereas nitroprusside was ineffective in two out of seven patients (not significant), who were finally treated effectively with the combination of the study drugs. Whenever monotherapy failed, both drugs together were effective in reducing the postoperative activation of the sympathetic and renin-angiotensin systems.

Original language	English
Pages (from-to)	111-115
Number of pages	5
Journal	Interactive Cardiovascular and Thoracic Surgery
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/S1569-9293(02)00115-9
State	Published - Jun 2003
Externally published	Yes

Keywords

Catecholamine
Coarctation
Esmolol
Nitroprusside
Renin

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10.1016/S1569-9293(02)00115-9

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title = "Comparison of sodium nitroprusside versus esmolol for the treatment of hypertension following repair of coarctation of the aorta",

abstract = "Postoperative arterial hypertension was treated with nitroprusside or esmolol in a prospective randomized study. If treatment failed, patients were first switched over to the other study drug, and then to a combination of both. Renin, angiotensin II, epinephrine, and norepinephrine were measured before, 1, and 17 h after operation. esmolol was effective in all cases of treatment (n=6) whereas nitroprusside was ineffective in two out of seven patients (not significant), who were finally treated effectively with the combination of the study drugs. Whenever monotherapy failed, both drugs together were effective in reducing the postoperative activation of the sympathetic and renin-angiotensin systems.",

keywords = "Catecholamine, Coarctation, Esmolol, Nitroprusside, Renin",

author = "Sven Dittrich and Joannis Germanakis and Heike Dittrich and Ingo Daehnert and Peter Ewert and Vladimir Alexi-Meskishvili and Michael Vogel and Lange, {Peter E.}",

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T1 - Comparison of sodium nitroprusside versus esmolol for the treatment of hypertension following repair of coarctation of the aorta

AU - Dittrich, Sven

AU - Germanakis, Joannis

AU - Dittrich, Heike

AU - Daehnert, Ingo

AU - Ewert, Peter

AU - Alexi-Meskishvili, Vladimir

AU - Vogel, Michael

AU - Lange, Peter E.

PY - 2003/6

Y1 - 2003/6

N2 - Postoperative arterial hypertension was treated with nitroprusside or esmolol in a prospective randomized study. If treatment failed, patients were first switched over to the other study drug, and then to a combination of both. Renin, angiotensin II, epinephrine, and norepinephrine were measured before, 1, and 17 h after operation. esmolol was effective in all cases of treatment (n=6) whereas nitroprusside was ineffective in two out of seven patients (not significant), who were finally treated effectively with the combination of the study drugs. Whenever monotherapy failed, both drugs together were effective in reducing the postoperative activation of the sympathetic and renin-angiotensin systems.

AB - Postoperative arterial hypertension was treated with nitroprusside or esmolol in a prospective randomized study. If treatment failed, patients were first switched over to the other study drug, and then to a combination of both. Renin, angiotensin II, epinephrine, and norepinephrine were measured before, 1, and 17 h after operation. esmolol was effective in all cases of treatment (n=6) whereas nitroprusside was ineffective in two out of seven patients (not significant), who were finally treated effectively with the combination of the study drugs. Whenever monotherapy failed, both drugs together were effective in reducing the postoperative activation of the sympathetic and renin-angiotensin systems.

KW - Catecholamine

KW - Coarctation

KW - Esmolol

KW - Nitroprusside

KW - Renin

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DO - 10.1016/S1569-9293(02)00115-9

M3 - Review article

AN - SCOPUS:1542400042

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VL - 2

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JO - Interactive Cardiovascular and Thoracic Surgery

JF - Interactive Cardiovascular and Thoracic Surgery

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ER -

Comparison of sodium nitroprusside versus esmolol for the treatment of hypertension following repair of coarctation of the aorta

Abstract

Keywords

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