Comparison of acquisition schemes for hyperpolarised 13C imaging

Markus Durst, Ulrich Koellisch, Annette Frank, Giaime Rancan, Concetta V. Gringeri, Vincent Karas, Florian Wiesinger, Marion I. Menzel, Markus Schwaiger, Axel Haase, Rolf F. Schulte

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

The aim of this study was to characterise and compare widely used acquisition strategies for hyperpolarised 13C imaging. Free induction decay chemical shift imaging (FIDCSI), echo-planar spectroscopic imaging (EPSI), IDEAL spiral chemical shift imaging (ISPCSI) and spiral chemical shift imaging (SPCSI) sequences were designed for two different regimes of spatial resolution. Their characteristics were studied in simulations and in tumour-bearing rats after injection of hyperpolarised [1-13C]pyruvate on a clinical 3-T scanner. Two or three different sequences were used on the same rat in random order for direct comparison. The experimentally obtained lactate signal-to-noise ratio (SNR) in the tumour matched the simulations. Differences between the sequences were mainly found in the encoding efficiency, gradient demand and artefact behaviour. Although ISPCSI and SPCSI offer high encoding efficiencies, these non-Cartesian trajectories are more prone than EPSI and FIDCSI to artefacts from various sources. If the encoding efficiency is sufficient for the desired application, EPSI has been proven to be a robust choice. Otherwise, faster spiral acquisition schemes are recommended. The conclusions found in this work can be applied directly to clinical applications.

Original languageEnglish
Pages (from-to)715-725
Number of pages11
JournalNMR in Biomedicine
Volume28
Issue number6
DOIs
StatePublished - 1 Jun 2015

Keywords

  • Hyperpolarised C
  • Metabolic imaging
  • Pyruvate
  • Tumour

Fingerprint

Dive into the research topics of 'Comparison of acquisition schemes for hyperpolarised 13C imaging'. Together they form a unique fingerprint.

Cite this