Comparison between 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography and positron emission tomography/computed tomography hardware fusion for staging of patients with lymphoma

Martin Allen-Auerbach, Andrew Quon, Wolfgang A. Weber, Sebastian Obrzut, Tyler Crawford, Daniel H.S. Silverman, Osman Ratib, Michael E. Phelps, Johannes Czernin

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

Purpose: 2-Deoxy-2-[18F]fluoro-D-Glucose positron emission tomography (FDG-PET) stages patients with Hodgkin's disease (HD) and Non-Hodgkin's lymphoma (NHL) with higher accuracy than computed tomography (CT). We sought to determine whether integrated (hardware) fused PET/CT imaging results in further improvements in staging accuracy. Procedures: Seventy-three patients (age 51 ± 17 years, 37 female, 36 male) with HD (n = 20) or NHL (n = 53) undergoing staging were studied with an integrated PET/CT system. Image findings were verified by clinical follow up, additional imaging and when available, histology. Results: Thirty-four of 73 patients (46.5%) had evidence of disease and 39 were disease free as confirmed by clinical evaluation and follow-up for 41 ± 22 weeks (n = 73), including biopsy (n = 26), and other imaging modalities (n = 52) when available. A discordant image interpretation between PET and PET/CT occurred in seven patients (10%). PET/CT correctly upstaged two and downstaged five patients. Overall staging was accurate in 93% with PET/CT and 84% with PET (P = 0.03). Conclusion: Lymphoma is staged with higher accuracy using PET/CT than PET alone.

Original languageEnglish
Pages (from-to)411-416
Number of pages6
JournalMolecular Imaging and Biology
Volume6
Issue number6
DOIs
StatePublished - Nov 2004
Externally publishedYes

Keywords

  • FDG-PET
  • Lymphoma
  • PET/CT
  • Software fusion
  • Staging

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