Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development

Vishal C. Kalel; Pascal Mäser; Michael Sattler; Ralf Erdmann; Grzegorz M. Popowicz

doi:10.1016/j.mib.2018.11.003

Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development

Vishal C. Kalel, Pascal Mäser, Michael Sattler, Ralf Erdmann, Grzegorz M. Popowicz

Chair of Biomolecular NMR-Spectroscopy

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids’ glycosomal transport components as targets for new trypanocidal therapies.

Original language	English
Pages (from-to)	116-122
Number of pages	7
Journal	Current Opinion in Microbiology
Volume	46
DOIs	https://doi.org/10.1016/j.mib.2018.11.003
State	Published - Dec 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.mib.2018.11.003

Cite this

@article{69f1f57a18944b5eac339da51ee81e7f,

title = "Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development",

abstract = "Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids{\textquoteright} glycosomal transport components as targets for new trypanocidal therapies.",

author = "Kalel, {Vishal C.} and Pascal M{\"a}ser and Michael Sattler and Ralf Erdmann and Popowicz, {Grzegorz M.}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

month = dec,

doi = "10.1016/j.mib.2018.11.003",

language = "English",

volume = "46",

pages = "116--122",

journal = "Current Opinion in Microbiology",

issn = "1369-5274",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Come, sweet death

T2 - targeting glycosomal protein import for antitrypanosomal drug development

AU - Kalel, Vishal C.

AU - Mäser, Pascal

AU - Sattler, Michael

AU - Erdmann, Ralf

AU - Popowicz, Grzegorz M.

PY - 2018/12

Y1 - 2018/12

N2 - Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids’ glycosomal transport components as targets for new trypanocidal therapies.

AB - Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids’ glycosomal transport components as targets for new trypanocidal therapies.

UR - http://www.scopus.com/inward/record.url?scp=85057078424&partnerID=8YFLogxK

U2 - 10.1016/j.mib.2018.11.003

DO - 10.1016/j.mib.2018.11.003

M3 - Review article

C2 - 30481613

AN - SCOPUS:85057078424

SN - 1369-5274

VL - 46

SP - 116

EP - 122

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

ER -

Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this