Combinatorial and rational strategies to develop nonpeptidic α4β7-integrin antagonists from cyclic peptides

Dirk Gottschling; Jürgen Boer; Anja Schuster; Bernhard Holzmann; Horst Kessler

doi:10.1002/1521-3773(20020816)41:16<3007::AID-ANIE3007>3.0.CO;2-3

Combinatorial and rational strategies to develop nonpeptidic α4β7-integrin antagonists from cyclic peptides

Dirk Gottschling, Jürgen Boer, Anja Schuster, Bernhard Holzmann, Horst Kessler

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Non-peptidic compounds (e.g. 2) derived from cyclic peptides such as 1 are able to inhibit the α4β7-integrin/MAdCAM-1 interaction. 3-Amino arylpropionic acids are valuable dipeptide mimetics. MAdCAM-1 = mucosal addressin cell-adhesion molecule 1.

Original language	English
Pages (from-to)	3007-3011
Number of pages	5
Journal	Angewandte Chemie International Edition in English
Volume	41
Issue number	16
DOIs	https://doi.org/10.1002/1521-3773(20020816)41:16<3007::AID-ANIE3007>3.0.CO;2-3
State	Published - 16 Aug 2002

Keywords

Drug research
Inhibitors
Integrins
Medicinal chemistry
Peptidomimetics

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10.1002/1521-3773(20020816)41:16<3007::AID-ANIE3007>3.0.CO;2-3

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AU - Schuster, Anja

AU - Holzmann, Bernhard

AU - Kessler, Horst

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AB - Non-peptidic compounds (e.g. 2) derived from cyclic peptides such as 1 are able to inhibit the α4β7-integrin/MAdCAM-1 interaction. 3-Amino arylpropionic acids are valuable dipeptide mimetics. MAdCAM-1 = mucosal addressin cell-adhesion molecule 1.

KW - Drug research

KW - Inhibitors

KW - Integrins

KW - Medicinal chemistry

KW - Peptidomimetics

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Combinatorial and rational strategies to develop nonpeptidic α4β7-integrin antagonists from cyclic peptides

Abstract

Keywords

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