Columba S: A scalable co-layout design automation tool for microfluidic large-scale integration

Tsun Ming Tseng; Mengchu Li; Daniel Nestor Freitas; Amy Mongersun; Ismail Emre Araci; Tsung Yi Ho; Ulf Schlichtmann

doi:10.1145/3195970.3196011

Columba S: A scalable co-layout design automation tool for microfluidic large-scale integration

Tsun Ming Tseng
, Mengchu Li
, Daniel Nestor Freitas
, Amy Mongersun
, Ismail Emre Araci
, Tsung Yi Ho
, Ulf Schlichtmann

Chair of Electronic Design Automation

Technical University of Munich
Ludwig-Maximilians-Universität München
Santa Clara University
National Tsing Hua University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

21 Scopus citations

Abstract

Microfluidic large-scale integration (mLSI) is a promising platform for high-throughput biological applications. De-sign automation for mLSI has made much progress in recent years. Columba and its succeeding work Columba 2.0 pro-posed a mathematical modeling method that enables auto-matic design of manufacturing-ready chips within minutes. However, current approaches suffer from a huge computation load when the designs become larger. Thus, in this work, we propose Columba S with a focus on scalability. Columba S applies a new architectural framework and a straight channel routing discipline, and synthesizes multiplexers for efficient and reconfigurable valve control. Experiments show that Columba S is able to generate mLSI designs with more than 200 functional units within three minutes, which enables the design of a platform for large and complex applications.

Original language	English
Title of host publication	Proceedings of the 55th Annual Design Automation Conference, DAC 2018
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Print)	9781450357005
DOIs	https://doi.org/10.1145/3195970.3196011
State	Published - 24 Jun 2018
Event	55th Annual Design Automation Conference, DAC 2018 - San Francisco, United States Duration: 24 Jun 2018 → 29 Jun 2018

Publication series

Name	Proceedings - Design Automation Conference
Volume	Part F137710
ISSN (Print)	0738-100X

Conference

Conference	55th Annual Design Automation Conference, DAC 2018
Country/Territory	United States
City	San Francisco
Period	24/06/18 → 29/06/18

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Access to Document

10.1145/3195970.3196011

Cite this

Tseng, T. M., Li, M., Freitas, D. N., Mongersun, A., Araci, I. E., Ho, T. Y., & Schlichtmann, U. (2018). Columba S: A scalable co-layout design automation tool for microfluidic large-scale integration. In Proceedings of the 55th Annual Design Automation Conference, DAC 2018 Article a163 (Proceedings - Design Automation Conference; Vol. Part F137710). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1145/3195970.3196011

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title = "Columba S: A scalable co-layout design automation tool for microfluidic large-scale integration",

abstract = "Microfluidic large-scale integration (mLSI) is a promising platform for high-throughput biological applications. De-sign automation for mLSI has made much progress in recent years. Columba and its succeeding work Columba 2.0 pro-posed a mathematical modeling method that enables auto-matic design of manufacturing-ready chips within minutes. However, current approaches suffer from a huge computation load when the designs become larger. Thus, in this work, we propose Columba S with a focus on scalability. Columba S applies a new architectural framework and a straight channel routing discipline, and synthesizes multiplexers for efficient and reconfigurable valve control. Experiments show that Columba S is able to generate mLSI designs with more than 200 functional units within three minutes, which enables the design of a platform for large and complex applications.",

author = "Tseng, \{Tsun Ming\} and Mengchu Li and Freitas, \{Daniel Nestor\} and Amy Mongersun and Araci, \{Ismail Emre\} and Ho, \{Tsung Yi\} and Ulf Schlichtmann",

note = "Publisher Copyright: {\textcopyright} 2018 Association for Computing Machinery.; 55th Annual Design Automation Conference, DAC 2018 ; Conference date: 24-06-2018 Through 29-06-2018",

year = "2018",

month = jun,

day = "24",

doi = "10.1145/3195970.3196011",

language = "English",

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series = "Proceedings - Design Automation Conference",

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Tseng, TM, Li, M, Freitas, DN, Mongersun, A, Araci, IE, Ho, TY & Schlichtmann, U 2018, Columba S: A scalable co-layout design automation tool for microfluidic large-scale integration. in Proceedings of the 55th Annual Design Automation Conference, DAC 2018., a163, Proceedings - Design Automation Conference, vol. Part F137710, Institute of Electrical and Electronics Engineers Inc., 55th Annual Design Automation Conference, DAC 2018, San Francisco, United States, 24/06/18. https://doi.org/10.1145/3195970.3196011

Columba S: A scalable co-layout design automation tool for microfluidic large-scale integration. / Tseng, Tsun Ming; Li, Mengchu; Freitas, Daniel Nestor et al.
Proceedings of the 55th Annual Design Automation Conference, DAC 2018. Institute of Electrical and Electronics Engineers Inc., 2018. a163 (Proceedings - Design Automation Conference; Vol. Part F137710).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Columba S

T2 - 55th Annual Design Automation Conference, DAC 2018

AU - Tseng, Tsun Ming

AU - Li, Mengchu

AU - Freitas, Daniel Nestor

AU - Mongersun, Amy

AU - Araci, Ismail Emre

AU - Ho, Tsung Yi

AU - Schlichtmann, Ulf

PY - 2018/6/24

Y1 - 2018/6/24

N2 - Microfluidic large-scale integration (mLSI) is a promising platform for high-throughput biological applications. De-sign automation for mLSI has made much progress in recent years. Columba and its succeeding work Columba 2.0 pro-posed a mathematical modeling method that enables auto-matic design of manufacturing-ready chips within minutes. However, current approaches suffer from a huge computation load when the designs become larger. Thus, in this work, we propose Columba S with a focus on scalability. Columba S applies a new architectural framework and a straight channel routing discipline, and synthesizes multiplexers for efficient and reconfigurable valve control. Experiments show that Columba S is able to generate mLSI designs with more than 200 functional units within three minutes, which enables the design of a platform for large and complex applications.

AB - Microfluidic large-scale integration (mLSI) is a promising platform for high-throughput biological applications. De-sign automation for mLSI has made much progress in recent years. Columba and its succeeding work Columba 2.0 pro-posed a mathematical modeling method that enables auto-matic design of manufacturing-ready chips within minutes. However, current approaches suffer from a huge computation load when the designs become larger. Thus, in this work, we propose Columba S with a focus on scalability. Columba S applies a new architectural framework and a straight channel routing discipline, and synthesizes multiplexers for efficient and reconfigurable valve control. Experiments show that Columba S is able to generate mLSI designs with more than 200 functional units within three minutes, which enables the design of a platform for large and complex applications.

UR - https://www.scopus.com/pages/publications/85053688651

U2 - 10.1145/3195970.3196011

DO - 10.1145/3195970.3196011

M3 - Conference contribution

AN - SCOPUS:85053688651

SN - 9781450357005

T3 - Proceedings - Design Automation Conference

BT - Proceedings of the 55th Annual Design Automation Conference, DAC 2018

PB - Institute of Electrical and Electronics Engineers Inc.

Y2 - 24 June 2018 through 29 June 2018

ER -

Tseng TM, Li M, Freitas DN, Mongersun A, Araci IE, Ho TY et al. Columba S: A scalable co-layout design automation tool for microfluidic large-scale integration. In Proceedings of the 55th Annual Design Automation Conference, DAC 2018. Institute of Electrical and Electronics Engineers Inc. 2018. a163. (Proceedings - Design Automation Conference). doi: 10.1145/3195970.3196011

Columba S: A scalable co-layout design automation tool for microfluidic large-scale integration

Abstract

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