Columba: Co-layout synthesis for continuous-flow microfluidic biochips

Tsun Ming Tseng, Mengchu Li, Bing Li, Tsung Yi Ho, Ulf Schlichtmann

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

39 Scopus citations


Continuous-flow microfluidics have evolved rapidly in the last decades, due to their advantages in effective and accurate control. However, complex control results in complicated valve actuations. As a result, sophisticated interactions between control and flow layers substantially raise the design difficulty. Previous work on design automation for microfluidics neglects the interactions between the control and flow layers and designs each layer separately, which leads to unrealistic designs. We propose the first planarity-guaranteed architectural model, and the first physical-design module models for important microfluidic components, which have modelled the interactions between both control and flow layers, while reducing the design difficulty. Based on the above, we propose the co-layout synthesis tool called Columba, which considers the pressure sharing among different valves, and routes channels in an any-angled manner. Experimental results show that complicated designs considering layer interactions can be synthesized for the first time.

Original languageEnglish
Title of host publicationProceedings of the 53rd Annual Design Automation Conference, DAC 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781450342360
StatePublished - 5 Jun 2016
Event53rd Annual ACM IEEE Design Automation Conference, DAC 2016 - Austin, United States
Duration: 5 Jun 20169 Jun 2016

Publication series

NameProceedings - Design Automation Conference
ISSN (Print)0738-100X


Conference53rd Annual ACM IEEE Design Automation Conference, DAC 2016
Country/TerritoryUnited States


Dive into the research topics of 'Columba: Co-layout synthesis for continuous-flow microfluidic biochips'. Together they form a unique fingerprint.

Cite this