Collagenase activity in the cervix of non-pregnant and pregnant women

R. Osmers, W. Rath, B. C. Adelmann-Grill, C. Fittkow, M. Severényi, W. Kuhn

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Cervical biopsies were obtained from non pregnant patients and from pregnant at various stages of gestation and during labour. The tissues were extract with a Ca++-containing buffer, and collagenase activity was determined in these extracts using a solid phase assay in which triple helical125I-labelled collagen was cleaved. Collagenase was detected in all samples but significantly elevated activity was only present in labour at 6-8 cm cervical dilatation. This provides direct evidence for the crucial role of specific collagen degradation during cervical ripening and dilatation.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalArchives of Gynecology and Obstetrics
Issue number2
StatePublished - Nov 1990
Externally publishedYes


  • Cervix uteri
  • Collagenase
  • Parturition
  • Pregnancy


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