Cognitive impairment, clinical severity and MRI changes in MELAS syndrome

Torsten Kraya, Lena Neumann, Yvonne Paelecke-Habermann, Marcus Deschauer, Dietrich Stoevesandt, Stephan Zierz, Stefan Watzke

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Objective: To examine clinical severity, cognitive impairment, and MRI changes in patients with MELAS syndrome. Methods: Cognitive-mnestic functions, brain MRI (lesion load, cella media index) and clinical severity of ten patients with MELAS syndrome were examined. All patients carried the m.3243A > G mutation. Results: The detailed neuropsychological assessment revealed cognitive deficits in attention, executive function, visuoperception, and -construction. There were significant correlations between these cognitive changes, lesion load in MRI, disturbances in everyday life (clinical scale), and high scores in NMDAS. Conclusion: Patients with MELAS syndrome showed no global neuropsychological deficit, but rather distinct cognitive deficits.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
StatePublished - Jan 2019
Externally publishedYes


  • Cognitive impairment
  • Dementia
  • MRI
  • Mitochondrial disorders


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