Cognitive impairment, clinical severity and MRI changes in MELAS syndrome

Torsten Kraya; Lena Neumann; Yvonne Paelecke-Habermann; Marcus Deschauer; Dietrich Stoevesandt; Stephan Zierz; Stefan Watzke

doi:10.1016/j.mito.2017.12.012

Cognitive impairment, clinical severity and MRI changes in MELAS syndrome

Torsten Kraya, Lena Neumann, Yvonne Paelecke-Habermann, Marcus Deschauer, Dietrich Stoevesandt, Stephan Zierz, Stefan Watzke

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Objective: To examine clinical severity, cognitive impairment, and MRI changes in patients with MELAS syndrome. Methods: Cognitive-mnestic functions, brain MRI (lesion load, cella media index) and clinical severity of ten patients with MELAS syndrome were examined. All patients carried the m.3243A > G mutation. Results: The detailed neuropsychological assessment revealed cognitive deficits in attention, executive function, visuoperception, and -construction. There were significant correlations between these cognitive changes, lesion load in MRI, disturbances in everyday life (clinical scale), and high scores in NMDAS. Conclusion: Patients with MELAS syndrome showed no global neuropsychological deficit, but rather distinct cognitive deficits.

Original language	English
Pages (from-to)	53-57
Number of pages	5
Journal	Mitochondrion
Volume	44
DOIs	https://doi.org/10.1016/j.mito.2017.12.012
State	Published - Jan 2019
Externally published	Yes

Keywords

Cognitive impairment
Dementia
MELAS
MRI
Mitochondrial disorders

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10.1016/j.mito.2017.12.012

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title = "Cognitive impairment, clinical severity and MRI changes in MELAS syndrome",

abstract = "Objective: To examine clinical severity, cognitive impairment, and MRI changes in patients with MELAS syndrome. Methods: Cognitive-mnestic functions, brain MRI (lesion load, cella media index) and clinical severity of ten patients with MELAS syndrome were examined. All patients carried the m.3243A > G mutation. Results: The detailed neuropsychological assessment revealed cognitive deficits in attention, executive function, visuoperception, and -construction. There were significant correlations between these cognitive changes, lesion load in MRI, disturbances in everyday life (clinical scale), and high scores in NMDAS. Conclusion: Patients with MELAS syndrome showed no global neuropsychological deficit, but rather distinct cognitive deficits.",

keywords = "Cognitive impairment, Dementia, MELAS, MRI, Mitochondrial disorders",

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AU - Kraya, Torsten

AU - Neumann, Lena

AU - Paelecke-Habermann, Yvonne

AU - Deschauer, Marcus

AU - Stoevesandt, Dietrich

AU - Zierz, Stephan

AU - Watzke, Stefan

PY - 2019/1

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N2 - Objective: To examine clinical severity, cognitive impairment, and MRI changes in patients with MELAS syndrome. Methods: Cognitive-mnestic functions, brain MRI (lesion load, cella media index) and clinical severity of ten patients with MELAS syndrome were examined. All patients carried the m.3243A > G mutation. Results: The detailed neuropsychological assessment revealed cognitive deficits in attention, executive function, visuoperception, and -construction. There were significant correlations between these cognitive changes, lesion load in MRI, disturbances in everyday life (clinical scale), and high scores in NMDAS. Conclusion: Patients with MELAS syndrome showed no global neuropsychological deficit, but rather distinct cognitive deficits.

AB - Objective: To examine clinical severity, cognitive impairment, and MRI changes in patients with MELAS syndrome. Methods: Cognitive-mnestic functions, brain MRI (lesion load, cella media index) and clinical severity of ten patients with MELAS syndrome were examined. All patients carried the m.3243A > G mutation. Results: The detailed neuropsychological assessment revealed cognitive deficits in attention, executive function, visuoperception, and -construction. There were significant correlations between these cognitive changes, lesion load in MRI, disturbances in everyday life (clinical scale), and high scores in NMDAS. Conclusion: Patients with MELAS syndrome showed no global neuropsychological deficit, but rather distinct cognitive deficits.

KW - Cognitive impairment

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KW - Mitochondrial disorders

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Cognitive impairment, clinical severity and MRI changes in MELAS syndrome

Abstract

Keywords

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