Cognate interaction between endothelial cells and T cells

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

11 Scopus citations


Endothelial cells lining the blood vessels form a barrier between circulating immune cells and parenchymal tissue. While the molecular mechanisms involved in antigen-independent recruitment of leukocytes into infected tissue have been extensively studied, the mechanisms involving antigen-specific recruitment of T cells into tissue have remained largely elusive. Here I shall review the experimental evidence that endothelial cells function as antigen-presenting cells and in this function contribute first to regulation of immune responses and second, to antigen-specific recruitment of T cells.

Original languageEnglish
Title of host publicationCell Communication in Nervous and Immune System
EditorsEckhart Gundelfinger, Constanze Seidenbecher, Bukhart Schraven
Number of pages23
StatePublished - 2006
Externally publishedYes

Publication series

NameResults and Problems in Cell Differentiation
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412


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