Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness

Y. Yamanaka; H. Friess; M. S. Kobrin; M. Buchler; H. G. Beger; M. Korc

Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness

Y. Yamanaka
, H. Friess
, M. S. Kobrin
, M. Buchler
, H. G. Beger
, M. Korc

University of California, Irvine

Research output: Contribution to journal › Article › peer-review

407 Scopus citations

Abstract

Immunohistochemical analysis for the epidermal growth factor receptor (EGFR), EGF and transforming growth factor-alpha (TGF-α) was performed in 87 human pancreatic carcinomas. Expression frequencies for EGFR, EGF, and TGF-α were 43%, 46% and 54%, respectively. Coexpression of the receptor and at least one of its ligands occurred in 38% of the tumors, and correlated with large tumor size, advanced clinical staging, and decreased survival period. In situ hybridization revealed that the respective mRNAs were also overexpressed in the carcinomas. These findigs suggest that coexpression of EGFR and its ligands may contribute to the aggressiveness of human pancreatic cancer.

Original language	English
Pages (from-to)	565-570
Number of pages	6
Journal	Anticancer Research
Volume	13
Issue number	3
State	Published - 1993
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Epidermal growth factor
Epidermal growth factor receptor
Human pancreatic cancer
Transforming growth factor alpha

Cite this

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title = "Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness",

abstract = "Immunohistochemical analysis for the epidermal growth factor receptor (EGFR), EGF and transforming growth factor-alpha (TGF-α) was performed in 87 human pancreatic carcinomas. Expression frequencies for EGFR, EGF, and TGF-α were 43\%, 46\% and 54\%, respectively. Coexpression of the receptor and at least one of its ligands occurred in 38\% of the tumors, and correlated with large tumor size, advanced clinical staging, and decreased survival period. In situ hybridization revealed that the respective mRNAs were also overexpressed in the carcinomas. These findigs suggest that coexpression of EGFR and its ligands may contribute to the aggressiveness of human pancreatic cancer.",

keywords = "Epidermal growth factor, Epidermal growth factor receptor, Human pancreatic cancer, Transforming growth factor alpha",

author = "Y. Yamanaka and H. Friess and Kobrin, \{M. S.\} and M. Buchler and Beger, \{H. G.\} and M. Korc",

year = "1993",

language = "English",

volume = "13",

pages = "565--570",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "3",

}

TY - JOUR

T1 - Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness

AU - Yamanaka, Y.

AU - Friess, H.

AU - Kobrin, M. S.

AU - Buchler, M.

AU - Beger, H. G.

AU - Korc, M.

PY - 1993

Y1 - 1993

N2 - Immunohistochemical analysis for the epidermal growth factor receptor (EGFR), EGF and transforming growth factor-alpha (TGF-α) was performed in 87 human pancreatic carcinomas. Expression frequencies for EGFR, EGF, and TGF-α were 43%, 46% and 54%, respectively. Coexpression of the receptor and at least one of its ligands occurred in 38% of the tumors, and correlated with large tumor size, advanced clinical staging, and decreased survival period. In situ hybridization revealed that the respective mRNAs were also overexpressed in the carcinomas. These findigs suggest that coexpression of EGFR and its ligands may contribute to the aggressiveness of human pancreatic cancer.

AB - Immunohistochemical analysis for the epidermal growth factor receptor (EGFR), EGF and transforming growth factor-alpha (TGF-α) was performed in 87 human pancreatic carcinomas. Expression frequencies for EGFR, EGF, and TGF-α were 43%, 46% and 54%, respectively. Coexpression of the receptor and at least one of its ligands occurred in 38% of the tumors, and correlated with large tumor size, advanced clinical staging, and decreased survival period. In situ hybridization revealed that the respective mRNAs were also overexpressed in the carcinomas. These findigs suggest that coexpression of EGFR and its ligands may contribute to the aggressiveness of human pancreatic cancer.

KW - Epidermal growth factor

KW - Epidermal growth factor receptor

KW - Human pancreatic cancer

KW - Transforming growth factor alpha

UR - https://www.scopus.com/pages/publications/0027293748

M3 - Article

C2 - 8317885

AN - SCOPUS:0027293748

SN - 0250-7005

VL - 13

SP - 565

EP - 570

JO - Anticancer Research

JF - Anticancer Research

IS - 3

ER -

Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness

Abstract

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Keywords

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