TY - JOUR
T1 - Clinician-Reported Negative Symptom Scales
T2 - A Systematic Review of Measurement Properties
AU - Weigel, Lucia
AU - Wehr, Sophia
AU - Galderisi, Silvana
AU - Mucci, Armida
AU - Davis, John M.
AU - Leucht, Stefan
N1 - Publisher Copyright:
© The Author(s) 2024. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please c
PY - 2024/12/20
Y1 - 2024/12/20
N2 - BACKGROUND: Negative symptoms of schizophrenia are correlated with reduction of normal function and lower quality of life. They were newly defined by the NIMH-MATRICS Consensus in 2005, dividing the rating tools to assess them into first-generation scales, developed before the Consensus, and second-generation scales, based on the recently introduced definitions. METHODS: The COnsensus-based Standards for the selection of health Measurement Instrument (COSMIN) guidelines for systematic reviews were used to evaluate the quality of psychometric data of the first-generation scales that cover the 5 negative symptom domains of the NIMHS Consensus: the Scale for the Assessment of Negative Symptoms (SANS), the High Royds Evaluation of Negativity Scale (HEN), and the Negative Symptom Assessment-16 (NSA-16). RESULTS: The search strategy resulted in the inclusion of a total of 13 articles, 7 for the SANS, 4 for the NSA-16, and 2 for the HEN. For the SANS and the NSA-16, the overall results of the scales' measurement properties are mostly insufficient or indeterminate. The quality of evidence for the HEN is poor, due to a small number of validation studies/included patients. CONCLUSIONS: After applying the COSMIN guidelines, we do not recommend the usage of these first-generation scales to rate negative symptoms. At the minimum they require further validation.
AB - BACKGROUND: Negative symptoms of schizophrenia are correlated with reduction of normal function and lower quality of life. They were newly defined by the NIMH-MATRICS Consensus in 2005, dividing the rating tools to assess them into first-generation scales, developed before the Consensus, and second-generation scales, based on the recently introduced definitions. METHODS: The COnsensus-based Standards for the selection of health Measurement Instrument (COSMIN) guidelines for systematic reviews were used to evaluate the quality of psychometric data of the first-generation scales that cover the 5 negative symptom domains of the NIMHS Consensus: the Scale for the Assessment of Negative Symptoms (SANS), the High Royds Evaluation of Negativity Scale (HEN), and the Negative Symptom Assessment-16 (NSA-16). RESULTS: The search strategy resulted in the inclusion of a total of 13 articles, 7 for the SANS, 4 for the NSA-16, and 2 for the HEN. For the SANS and the NSA-16, the overall results of the scales' measurement properties are mostly insufficient or indeterminate. The quality of evidence for the HEN is poor, due to a small number of validation studies/included patients. CONCLUSIONS: After applying the COSMIN guidelines, we do not recommend the usage of these first-generation scales to rate negative symptoms. At the minimum they require further validation.
KW - antipsychotic
KW - negative symptom
KW - scale
KW - schizophrenia
KW - validation
UR - http://www.scopus.com/inward/record.url?scp=85213596416&partnerID=8YFLogxK
U2 - 10.1093/schbul/sbae168
DO - 10.1093/schbul/sbae168
M3 - Article
C2 - 39422706
AN - SCOPUS:85213596416
SN - 0586-7614
VL - 51
SP - 3
EP - 16
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - 1
ER -
