Clinical severity of Alzheimer's disease is associated with PIB uptake in PET

Timo Grimmer; Gjermund Henriksen; Hans Jürgen Wester; Hans Förstl; William E. Klunk; Chester A. Mathis; Alexander Kurz; Alexander Drzezga

doi:10.1016/j.neurobiolaging.2008.01.016

Clinical severity of Alzheimer's disease is associated with PIB uptake in PET

Timo Grimmer
, Gjermund Henriksen
, Hans Jürgen Wester
, Hans Förstl
, William E. Klunk
, Chester A. Mathis
, Alexander Kurz
, Alexander Drzezga

Technical University of Munich
W. Psychiatric Institute and Clinic
University of Pittsburgh School of Medicine

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Background: The positron emission tomography (PET) tracer [11C]-Pittsburgh Compound-B ([11C]PIB) allows the in vivo assessment of amyloid plaque burden in the brain. In a cross-sectional study we examined the association between the severity of dementia assessed using the Clinical Dementia Rating scale sum of boxes (CDR-SOB) and [11C]PIB-PET in patients with Alzheimer's disease (AD). Methods: Patients with probable AD who had an AD-typical [18F]FDG-PET scan were included. Linear regression analysis in anatomically defined regions-of-interest (ROIs) and correlation analysis using statistical parametric mapping (SPM) were used to determine the association between CDR-SOB and [11C]PIB uptake. Results: The linear regression analyses showed that the CDR-SOB explained approximately 11-22% of the variance of [11C]PIB uptake. The association attained statistical significance in both frontal, in both anterior cingulate cortices, and in both putamina. The SPM analysis showed a significant association in more widespread regions of the brain, with maxima located in similar areas as in the ROI-analysis. Conclusion: The CDR-SOB score is significantly associated with [11C]PIB uptake in patients with AD. Thus [11C]PIB is a potential surrogate marker of dementia severity.

Original language	English
Pages (from-to)	1902-1909
Number of pages	8
Journal	Neurobiology of Aging
Volume	30
Issue number	12
DOIs	https://doi.org/10.1016/j.neurobiolaging.2008.01.016
State	Published - Dec 2009

Keywords

Alzheimer's disease
Amyloid plaques
Clinical Dementia Rating
Dementia
Imaging
Pittsburgh Compound B
Positron emission tomography
[11C]PIB
[18F]FDG

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10.1016/j.neurobiolaging.2008.01.016

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@article{37a68c2c4f0940208647ec228c33f75c,

title = "Clinical severity of Alzheimer's disease is associated with PIB uptake in PET",

abstract = "Background: The positron emission tomography (PET) tracer [11C]-Pittsburgh Compound-B ([11C]PIB) allows the in vivo assessment of amyloid plaque burden in the brain. In a cross-sectional study we examined the association between the severity of dementia assessed using the Clinical Dementia Rating scale sum of boxes (CDR-SOB) and [11C]PIB-PET in patients with Alzheimer's disease (AD). Methods: Patients with probable AD who had an AD-typical [18F]FDG-PET scan were included. Linear regression analysis in anatomically defined regions-of-interest (ROIs) and correlation analysis using statistical parametric mapping (SPM) were used to determine the association between CDR-SOB and [11C]PIB uptake. Results: The linear regression analyses showed that the CDR-SOB explained approximately 11-22\% of the variance of [11C]PIB uptake. The association attained statistical significance in both frontal, in both anterior cingulate cortices, and in both putamina. The SPM analysis showed a significant association in more widespread regions of the brain, with maxima located in similar areas as in the ROI-analysis. Conclusion: The CDR-SOB score is significantly associated with [11C]PIB uptake in patients with AD. Thus [11C]PIB is a potential surrogate marker of dementia severity.",

keywords = "Alzheimer's disease, Amyloid plaques, Clinical Dementia Rating, Dementia, Imaging, Pittsburgh Compound B, Positron emission tomography, [11C]PIB, [18F]FDG",

author = "Timo Grimmer and Gjermund Henriksen and Wester, \{Hans J{\"u}rgen\} and Hans F{\"o}rstl and Klunk, \{William E.\} and Mathis, \{Chester A.\} and Alexander Kurz and Alexander Drzezga",

note = "Funding Information: This work has been supported in part by a DFG-grant (Deutsche Forschungsgemeinschaft) Project Number: HE 4560/1-2 (A. Drzezga, G. Henriksen, H.J. Wester) and by a KKF-grant for clinical research of the Technische Universit{\"a}t M{\"u}nchen (A. Drzezga, T. Grimmer).",

year = "2009",

month = dec,

doi = "10.1016/j.neurobiolaging.2008.01.016",

language = "English",

volume = "30",

pages = "1902--1909",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "12",

}

TY - JOUR

T1 - Clinical severity of Alzheimer's disease is associated with PIB uptake in PET

AU - Grimmer, Timo

AU - Henriksen, Gjermund

AU - Wester, Hans Jürgen

AU - Förstl, Hans

AU - Klunk, William E.

AU - Mathis, Chester A.

AU - Kurz, Alexander

AU - Drzezga, Alexander

N1 - Funding Information: This work has been supported in part by a DFG-grant (Deutsche Forschungsgemeinschaft) Project Number: HE 4560/1-2 (A. Drzezga, G. Henriksen, H.J. Wester) and by a KKF-grant for clinical research of the Technische Universität München (A. Drzezga, T. Grimmer).

PY - 2009/12

Y1 - 2009/12

N2 - Background: The positron emission tomography (PET) tracer [11C]-Pittsburgh Compound-B ([11C]PIB) allows the in vivo assessment of amyloid plaque burden in the brain. In a cross-sectional study we examined the association between the severity of dementia assessed using the Clinical Dementia Rating scale sum of boxes (CDR-SOB) and [11C]PIB-PET in patients with Alzheimer's disease (AD). Methods: Patients with probable AD who had an AD-typical [18F]FDG-PET scan were included. Linear regression analysis in anatomically defined regions-of-interest (ROIs) and correlation analysis using statistical parametric mapping (SPM) were used to determine the association between CDR-SOB and [11C]PIB uptake. Results: The linear regression analyses showed that the CDR-SOB explained approximately 11-22% of the variance of [11C]PIB uptake. The association attained statistical significance in both frontal, in both anterior cingulate cortices, and in both putamina. The SPM analysis showed a significant association in more widespread regions of the brain, with maxima located in similar areas as in the ROI-analysis. Conclusion: The CDR-SOB score is significantly associated with [11C]PIB uptake in patients with AD. Thus [11C]PIB is a potential surrogate marker of dementia severity.

AB - Background: The positron emission tomography (PET) tracer [11C]-Pittsburgh Compound-B ([11C]PIB) allows the in vivo assessment of amyloid plaque burden in the brain. In a cross-sectional study we examined the association between the severity of dementia assessed using the Clinical Dementia Rating scale sum of boxes (CDR-SOB) and [11C]PIB-PET in patients with Alzheimer's disease (AD). Methods: Patients with probable AD who had an AD-typical [18F]FDG-PET scan were included. Linear regression analysis in anatomically defined regions-of-interest (ROIs) and correlation analysis using statistical parametric mapping (SPM) were used to determine the association between CDR-SOB and [11C]PIB uptake. Results: The linear regression analyses showed that the CDR-SOB explained approximately 11-22% of the variance of [11C]PIB uptake. The association attained statistical significance in both frontal, in both anterior cingulate cortices, and in both putamina. The SPM analysis showed a significant association in more widespread regions of the brain, with maxima located in similar areas as in the ROI-analysis. Conclusion: The CDR-SOB score is significantly associated with [11C]PIB uptake in patients with AD. Thus [11C]PIB is a potential surrogate marker of dementia severity.

KW - Alzheimer's disease

KW - Amyloid plaques

KW - Clinical Dementia Rating

KW - Dementia

KW - Imaging

KW - Pittsburgh Compound B

KW - Positron emission tomography

KW - [11C]PIB

KW - [18F]FDG

UR - https://www.scopus.com/pages/publications/70349860185

U2 - 10.1016/j.neurobiolaging.2008.01.016

DO - 10.1016/j.neurobiolaging.2008.01.016

M3 - Article

C2 - 18346821

AN - SCOPUS:70349860185

SN - 0197-4580

VL - 30

SP - 1902

EP - 1909

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 12

ER -

Clinical severity of Alzheimer's disease is associated with PIB uptake in PET

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