Clinical severity of Alzheimer's disease is associated with PIB uptake in PET

Timo Grimmer, Gjermund Henriksen, Hans Jürgen Wester, Hans Förstl, William E. Klunk, Chester A. Mathis, Alexander Kurz, Alexander Drzezga

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Background: The positron emission tomography (PET) tracer [11C]-Pittsburgh Compound-B ([11C]PIB) allows the in vivo assessment of amyloid plaque burden in the brain. In a cross-sectional study we examined the association between the severity of dementia assessed using the Clinical Dementia Rating scale sum of boxes (CDR-SOB) and [11C]PIB-PET in patients with Alzheimer's disease (AD). Methods: Patients with probable AD who had an AD-typical [18F]FDG-PET scan were included. Linear regression analysis in anatomically defined regions-of-interest (ROIs) and correlation analysis using statistical parametric mapping (SPM) were used to determine the association between CDR-SOB and [11C]PIB uptake. Results: The linear regression analyses showed that the CDR-SOB explained approximately 11-22% of the variance of [11C]PIB uptake. The association attained statistical significance in both frontal, in both anterior cingulate cortices, and in both putamina. The SPM analysis showed a significant association in more widespread regions of the brain, with maxima located in similar areas as in the ROI-analysis. Conclusion: The CDR-SOB score is significantly associated with [11C]PIB uptake in patients with AD. Thus [11C]PIB is a potential surrogate marker of dementia severity.

Original languageEnglish
Pages (from-to)1902-1909
Number of pages8
JournalNeurobiology of Aging
Volume30
Issue number12
DOIs
StatePublished - Dec 2009

Keywords

  • Alzheimer's disease
  • Amyloid plaques
  • Clinical Dementia Rating
  • Dementia
  • Imaging
  • Pittsburgh Compound B
  • Positron emission tomography
  • [11C]PIB
  • [18F]FDG

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