Clinical sciences and orthopaedics: Case report homozygous APC resistance in an elite athlete

Thomas Hilberg, G. Moessmer, M. Hartard, D. Jeschke

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We report the case of a 31 year old female elite athlete. During a routine check-up including a search for hereditary hemostatic risk factors for thrombosis, resistance to activated protein C was detected. Molecular analysis of the factor V gene revealed homozygosity for the factor V Leiden mutation. This is the first documented case of an elite athlete who is a homozygous carrier of factor V Leiden. Elite athletes may be exposed to several circumstantial thrombogenic risk factors and, therefore, special preventive measures in carriers of a congenital risk factor such as APC resistance are indicated. Essential measures are early anticoagulation during periods of immobilisation e.g. after sports-related injuries, a single dose of low-molecular-weight heparin specially for individuals with several thrombotic risk factors and/or leg muscle exercises for long-distance (air) travels and avoiding haemoconcentration with a sufficient oral fluid intake.

Original languageEnglish
Pages (from-to)198-200
Number of pages3
JournalInternational Journal of Sports Medicine
Issue number3
StatePublished - 1999


  • APC resistance
  • Elite athlete
  • Factor V Leiden
  • Homozygote
  • Sports activity
  • Thrombophilia
  • Thrombosis


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