@inbook{76bbe0db887847cc9ee3a487a4342c6f,
title = "Classification of atypical parkinsonism per pathology versus phenotype",
abstract = "The umbrella term “atypical parkinsonism” refers to a clinical presentation with various causes, emphasizing the clinical commonality of diseases in which atypical parkinsonism can present. This term is useful for describing the phenomenology of a movement disorder and to classify patients according to their clinical presentation. In contrast to this classification per phenotype, a classification per pathology is needed when it comes to understanding the pathogenesis and designing and delivering disease-modifying therapeutic interventions. Clinico-pathological correlation studies have revealed enormous clinical heterogeneity and vast clinical overlap in pathologically defined diseases related to atypical parkinsonism. Thus, the classification of patients with atypical parkinsonism per phenotype has limited validity for predicting the underlying pathology. This chapter will contrast the phenotype-driven classification and the pathology-driven classification of neurodegenerative diseases related to atypical parkinsonism and discuss future directions to improve pathology-specific diagnosis.",
keywords = "Atypical parkinsonism, Classification, Clinico-pathological correlation, Pathology, Phenotypes, Tauopathies, α-Synucleinopathies",
author = "Gesine Respondek and Maria Stamelou and H{\"o}glinger, {G{\"u}nter U.}",
note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
doi = "10.1016/bs.irn.2019.10.003",
language = "English",
isbn = "9780128177303",
series = "International Review of Neurobiology",
publisher = "Academic Press Inc.",
pages = "37--47",
editor = "Maria Stamelou and H{\"o}glinger, {G{\"u}nter U.}",
booktitle = "Parkinsonism Beyond Parkinson's Disease",
}