Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet

Fabiana Quagliarini; Ashfaq Ali Mir; Kinga Balazs; Michael Wierer; Kenneth Allen Dyar; Celine Jouffe; Konstantinos Makris; Johann Hawe; Matthias Heinig; Fabian Volker Filipp; Grant Daniel Barish; Nina Henriette Uhlenhaut

doi:10.1016/j.molcel.2019.10.007

Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet

Fabiana Quagliarini, Ashfaq Ali Mir, Kinga Balazs, Michael Wierer, Kenneth Allen Dyar, Celine Jouffe, Konstantinos Makris, Johann Hawe, Matthias Heinig, Fabian Volker Filipp, Grant Daniel Barish, Nina Henriette Uhlenhaut

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64 Scopus citations

Abstract

Glucocorticoid hormones are secreted with a prominent daily rhythm, but their diurnal genomic actions remain uncharacterized. Quagliarini et al. show how the glucocorticoid receptor controls daily cycles of glucose and triglyceride metabolism by time-dependent chromatin binding and target gene transcription and how this rhythm is augmented by high-fat diet.

Original language	English
Pages (from-to)	531-545.e5
Journal	Molecular Cell
Volume	76
Issue number	4
DOIs	https://doi.org/10.1016/j.molcel.2019.10.007
State	Published - 21 Nov 2019

Keywords

PPARα
STAT5
circadian clock
cistromes
glucocorticoid receptor
glucose and lipid metabolism
high-fat diet
hormones
mouse liver

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10.1016/j.molcel.2019.10.007

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title = "Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet",

abstract = "Glucocorticoid hormones are secreted with a prominent daily rhythm, but their diurnal genomic actions remain uncharacterized. Quagliarini et al. show how the glucocorticoid receptor controls daily cycles of glucose and triglyceride metabolism by time-dependent chromatin binding and target gene transcription and how this rhythm is augmented by high-fat diet.",

keywords = "PPARα, STAT5, circadian clock, cistromes, glucocorticoid receptor, glucose and lipid metabolism, high-fat diet, hormones, mouse liver",

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AU - Quagliarini, Fabiana

AU - Mir, Ashfaq Ali

AU - Balazs, Kinga

AU - Wierer, Michael

AU - Dyar, Kenneth Allen

AU - Jouffe, Celine

AU - Makris, Konstantinos

AU - Hawe, Johann

AU - Heinig, Matthias

AU - Filipp, Fabian Volker

AU - Barish, Grant Daniel

AU - Uhlenhaut, Nina Henriette

PY - 2019/11/21

Y1 - 2019/11/21

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AB - Glucocorticoid hormones are secreted with a prominent daily rhythm, but their diurnal genomic actions remain uncharacterized. Quagliarini et al. show how the glucocorticoid receptor controls daily cycles of glucose and triglyceride metabolism by time-dependent chromatin binding and target gene transcription and how this rhythm is augmented by high-fat diet.

KW - PPARα

KW - STAT5

KW - circadian clock

KW - cistromes

KW - glucocorticoid receptor

KW - glucose and lipid metabolism

KW - high-fat diet

KW - hormones

KW - mouse liver

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JO - Molecular Cell

JF - Molecular Cell

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ER -

Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet

Abstract

Keywords

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