Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

Nina Dedic; Claudia Kühne; Mira Jakovcevski; Jakob Hartmann; Andreas J. Genewsky; Karina S. Gomes; Elmira Anderzhanova; Max L. Pöhlmann; Simon Chang; Adam Kolarz; Annette M. Vogl; Julien Dine; Michael W. Metzger; Bianca Schmid; Rafael C. Almada; Kerry J. Ressler; Carsten T. Wotjak; Valery Grinevich; Alon Chen; Mathias V. Schmidt; Wolfgang Wurst; Damian Refojo; Jan M. Deussing

doi:10.1038/s41593-018-0151-z

Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

Nina Dedic
, Claudia Kühne
, Mira Jakovcevski
, Jakob Hartmann
, Andreas J. Genewsky
, Karina S. Gomes
, Elmira Anderzhanova
, Max L. Pöhlmann
, Simon Chang
, Adam Kolarz
, Annette M. Vogl
, Julien Dine
, Michael W. Metzger
, Bianca Schmid
, Rafael C. Almada
, Kerry J. Ressler
, Carsten T. Wotjak
, Valery Grinevich
, Alon Chen
, Mathias V. Schmidt

Wolfgang Wurst, Damian Refojo, Jan M. Deussing

Chair of Developmental Genetics

Max Planck Institute of Psychiatry
Harvard Medical School
São Paulo State University
Heidelberg University
Helmholtz Zentrum München German Research Center for Environmental Health
German Center for Neurodegenerative Diseases (DZNE)
Partner Institute of the Max Planck Society

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.

Original language	English
Pages (from-to)	803-807
Number of pages	5
Journal	Nature Neuroscience
Volume	21
Issue number	6
DOIs	https://doi.org/10.1038/s41593-018-0151-z
State	Published - 1 Jun 2018

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Dedic, N., Kühne, C., Jakovcevski, M., Hartmann, J., Genewsky, A. J., Gomes, K. S., Anderzhanova, E., Pöhlmann, M. L., Chang, S., Kolarz, A., Vogl, A. M., Dine, J., Metzger, M. W., Schmid, B., Almada, R. C., Ressler, K. J., Wotjak, C. T., Grinevich, V., Chen, A., ... Deussing, J. M. (2018). Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nature Neuroscience, 21(6), 803-807. https://doi.org/10.1038/s41593-018-0151-z

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title = "Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety",

abstract = "The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.",

author = "Nina Dedic and Claudia K{\"u}hne and Mira Jakovcevski and Jakob Hartmann and Genewsky, \{Andreas J.\} and Gomes, \{Karina S.\} and Elmira Anderzhanova and P{\"o}hlmann, \{Max L.\} and Simon Chang and Adam Kolarz and Vogl, \{Annette M.\} and Julien Dine and Metzger, \{Michael W.\} and Bianca Schmid and Almada, \{Rafael C.\} and Ressler, \{Kerry J.\} and Wotjak, \{Carsten T.\} and Valery Grinevich and Alon Chen and Schmidt, \{Mathias V.\} and Wolfgang Wurst and Damian Refojo and Deussing, \{Jan M.\}",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s).",

year = "2018",

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doi = "10.1038/s41593-018-0151-z",

language = "English",

volume = "21",

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Dedic, N, Kühne, C, Jakovcevski, M, Hartmann, J, Genewsky, AJ, Gomes, KS, Anderzhanova, E, Pöhlmann, ML, Chang, S, Kolarz, A, Vogl, AM, Dine, J, Metzger, MW, Schmid, B, Almada, RC, Ressler, KJ, Wotjak, CT, Grinevich, V, Chen, A, Schmidt, MV, Wurst, W, Refojo, D & Deussing, JM 2018, 'Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety', Nature Neuroscience, vol. 21, no. 6, pp. 803-807. https://doi.org/10.1038/s41593-018-0151-z

TY - JOUR

T1 - Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

AU - Dedic, Nina

AU - Kühne, Claudia

AU - Jakovcevski, Mira

AU - Hartmann, Jakob

AU - Genewsky, Andreas J.

AU - Gomes, Karina S.

AU - Anderzhanova, Elmira

AU - Pöhlmann, Max L.

AU - Chang, Simon

AU - Kolarz, Adam

AU - Vogl, Annette M.

AU - Dine, Julien

AU - Metzger, Michael W.

AU - Schmid, Bianca

AU - Almada, Rafael C.

AU - Ressler, Kerry J.

AU - Wotjak, Carsten T.

AU - Grinevich, Valery

AU - Chen, Alon

AU - Schmidt, Mathias V.

AU - Wurst, Wolfgang

AU - Refojo, Damian

AU - Deussing, Jan M.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.

AB - The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.

UR - https://www.scopus.com/pages/publications/85047204795

U2 - 10.1038/s41593-018-0151-z

DO - 10.1038/s41593-018-0151-z

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AN - SCOPUS:85047204795

SN - 1097-6256

VL - 21

SP - 803

EP - 807

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 6

ER -

Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

Abstract

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