Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

Nina Dedic, Claudia Kühne, Mira Jakovcevski, Jakob Hartmann, Andreas J. Genewsky, Karina S. Gomes, Elmira Anderzhanova, Max L. Pöhlmann, Simon Chang, Adam Kolarz, Annette M. Vogl, Julien Dine, Michael W. Metzger, Bianca Schmid, Rafael C. Almada, Kerry J. Ressler, Carsten T. Wotjak, Valery Grinevich, Alon Chen, Mathias V. SchmidtWolfgang Wurst, Damian Refojo, Jan M. Deussing

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.

Original languageEnglish
Pages (from-to)803-807
Number of pages5
JournalNature Neuroscience
Volume21
Issue number6
DOIs
StatePublished - 1 Jun 2018

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