Choriocapillaris flow density negatively correlates with advancing age on spectral-domain optical coherence tomography angiography

Moritz Pettenkofer; Pauline Scherm; Nikolaus Feucht; Klaus Wehrmann; Chris P. Lohmann; Mathias Maier

doi:10.3928/23258160-20190503-07

Choriocapillaris flow density negatively correlates with advancing age on spectral-domain optical coherence tomography angiography

Moritz Pettenkofer, Pauline Scherm, Nikolaus Feucht, Klaus Wehrmann, Chris P. Lohmann, Mathias Maier

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Technical University of Munich

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

BACKGROUND AND OBJECTIVE: To correlate subfoveal choriocapillaris (CC) flow density with age using spectral-domain optical coherence tomography angiography (SD-OCTA). PATIENTS AND METHODS: One hundred eighty-three eyes of 94 subjects (66 female, 28 male) were enrolled. Included were healthy subjects between the ages of 21 and 82 years without any history of vitreoretinal disease. Measurements were obtained with software from the OCT device. Significance was defined as a P value of less than .05. RESULTS: The mean age was 43.43 years ± 17.63 years. Correlation between decreasing CC flow density and increasing age was significant (P < .001), with a mean yearly flow decrease of 0.026%. Subfoveal choroidal thickness decreased with advancing age; however, this did not reach a level of significance (P = .069). CONCLUSION: There is a significantly negative correlation between CC flow density and advancing age in healthy subjects, analyzing direct extracted in-built software values from a commercial SD-OCTA device.

Original language	English
Pages (from-to)	302-308
Number of pages	7
Journal	Ophthalmic Surgery Lasers and Imaging Retina
Volume	50
Issue number	5
DOIs	https://doi.org/10.3928/23258160-20190503-07
State	Published - 2019

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@article{f8e09f8187214725b01411e58de51262,

title = "Choriocapillaris flow density negatively correlates with advancing age on spectral-domain optical coherence tomography angiography",

abstract = "BACKGROUND AND OBJECTIVE: To correlate subfoveal choriocapillaris (CC) flow density with age using spectral-domain optical coherence tomography angiography (SD-OCTA). PATIENTS AND METHODS: One hundred eighty-three eyes of 94 subjects (66 female, 28 male) were enrolled. Included were healthy subjects between the ages of 21 and 82 years without any history of vitreoretinal disease. Measurements were obtained with software from the OCT device. Significance was defined as a P value of less than .05. RESULTS: The mean age was 43.43 years ± 17.63 years. Correlation between decreasing CC flow density and increasing age was significant (P < .001), with a mean yearly flow decrease of 0.026%. Subfoveal choroidal thickness decreased with advancing age; however, this did not reach a level of significance (P = .069). CONCLUSION: There is a significantly negative correlation between CC flow density and advancing age in healthy subjects, analyzing direct extracted in-built software values from a commercial SD-OCTA device.",

author = "Moritz Pettenkofer and Pauline Scherm and Nikolaus Feucht and Klaus Wehrmann and Lohmann, {Chris P.} and Mathias Maier",

year = "2019",

doi = "10.3928/23258160-20190503-07",

language = "English",

volume = "50",

pages = "302--308",

journal = "Ophthalmic Surgery Lasers and Imaging Retina",

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TY - JOUR

T1 - Choriocapillaris flow density negatively correlates with advancing age on spectral-domain optical coherence tomography angiography

AU - Pettenkofer, Moritz

AU - Scherm, Pauline

AU - Feucht, Nikolaus

AU - Wehrmann, Klaus

AU - Lohmann, Chris P.

AU - Maier, Mathias

PY - 2019

Y1 - 2019

N2 - BACKGROUND AND OBJECTIVE: To correlate subfoveal choriocapillaris (CC) flow density with age using spectral-domain optical coherence tomography angiography (SD-OCTA). PATIENTS AND METHODS: One hundred eighty-three eyes of 94 subjects (66 female, 28 male) were enrolled. Included were healthy subjects between the ages of 21 and 82 years without any history of vitreoretinal disease. Measurements were obtained with software from the OCT device. Significance was defined as a P value of less than .05. RESULTS: The mean age was 43.43 years ± 17.63 years. Correlation between decreasing CC flow density and increasing age was significant (P < .001), with a mean yearly flow decrease of 0.026%. Subfoveal choroidal thickness decreased with advancing age; however, this did not reach a level of significance (P = .069). CONCLUSION: There is a significantly negative correlation between CC flow density and advancing age in healthy subjects, analyzing direct extracted in-built software values from a commercial SD-OCTA device.

AB - BACKGROUND AND OBJECTIVE: To correlate subfoveal choriocapillaris (CC) flow density with age using spectral-domain optical coherence tomography angiography (SD-OCTA). PATIENTS AND METHODS: One hundred eighty-three eyes of 94 subjects (66 female, 28 male) were enrolled. Included were healthy subjects between the ages of 21 and 82 years without any history of vitreoretinal disease. Measurements were obtained with software from the OCT device. Significance was defined as a P value of less than .05. RESULTS: The mean age was 43.43 years ± 17.63 years. Correlation between decreasing CC flow density and increasing age was significant (P < .001), with a mean yearly flow decrease of 0.026%. Subfoveal choroidal thickness decreased with advancing age; however, this did not reach a level of significance (P = .069). CONCLUSION: There is a significantly negative correlation between CC flow density and advancing age in healthy subjects, analyzing direct extracted in-built software values from a commercial SD-OCTA device.

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U2 - 10.3928/23258160-20190503-07

DO - 10.3928/23258160-20190503-07

M3 - Article

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AN - SCOPUS:85066253048

SN - 2325-8160

VL - 50

SP - 302

EP - 308

JO - Ophthalmic Surgery Lasers and Imaging Retina

JF - Ophthalmic Surgery Lasers and Imaging Retina

IS - 5

ER -

Choriocapillaris flow density negatively correlates with advancing age on spectral-domain optical coherence tomography angiography

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