Cholesterol and myelin biogenesis

Gesine Saher; Mikael Simons

doi:10.1007/978-90-481-8622-8_18

Cholesterol and myelin biogenesis

Gesine Saher, Mikael Simons

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Myelin consists of several layers of tightly compacted membranes wrapped around axons in the nervous system. The main function of myelin is to provide electrical insulation around the axon to ensure the rapid propagation of nerve conduction. As the myelinating glia terminally differentiates, they begin to produce myelin membranes on a remarkable scale. This membrane is unique in its composition being highly enriched in lipids, in particular galactosylceramide and cholesterol. In this review we will summarize the role of cholesterol in myelin biogenesis in the central and peripheral nervous system.

Original language	English
Pages (from-to)	489-508
Number of pages	20
Journal	Sub-Cellular Biochemistry
Volume	51
DOIs	https://doi.org/10.1007/978-90-481-8622-8_18
State	Published - 2010
Externally published	Yes

Keywords

Cholesterol
Myelin
Oligodendrocyte
Schwann cell

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-90-481-8622-8_18

Cite this

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AU - Saher, Gesine

AU - Simons, Mikael

N1 - Publisher Copyright: © Springer Science+Business Media B.V. 2010.

PY - 2010

Y1 - 2010

N2 - Myelin consists of several layers of tightly compacted membranes wrapped around axons in the nervous system. The main function of myelin is to provide electrical insulation around the axon to ensure the rapid propagation of nerve conduction. As the myelinating glia terminally differentiates, they begin to produce myelin membranes on a remarkable scale. This membrane is unique in its composition being highly enriched in lipids, in particular galactosylceramide and cholesterol. In this review we will summarize the role of cholesterol in myelin biogenesis in the central and peripheral nervous system.

AB - Myelin consists of several layers of tightly compacted membranes wrapped around axons in the nervous system. The main function of myelin is to provide electrical insulation around the axon to ensure the rapid propagation of nerve conduction. As the myelinating glia terminally differentiates, they begin to produce myelin membranes on a remarkable scale. This membrane is unique in its composition being highly enriched in lipids, in particular galactosylceramide and cholesterol. In this review we will summarize the role of cholesterol in myelin biogenesis in the central and peripheral nervous system.

KW - Cholesterol

KW - Myelin

KW - Oligodendrocyte

KW - Schwann cell

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JO - Sub-Cellular Biochemistry

JF - Sub-Cellular Biochemistry

ER -

Cholesterol and myelin biogenesis

Abstract

Keywords

UN SDGs

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