Cholestasis induced by hyperthyroidism after liver transplantation

Christian Lersch; Markus Seige; Walter Natrath; Wolfgang Heidecke; Christian Wittekind; Meinhard Classen; Wolfgang Schepp

doi:10.1159/000201271

Cholestasis induced by hyperthyroidism after liver transplantation

Christian Lersch
, Markus Seige
, Walter Natrath
, Wolfgang Heidecke
, Christian Wittekind
, Meinhard Classen
, Wolfgang Schepp

Friedrich Alexander Universität Erlangen-Nürnberg
Technical University of Munich

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We report the case of a 68-year-old woman who underwent liver transplantation because of hepatitis-C-induced cirrhosis. She developed iodine-induced hyperthyroidism postoperatively in temporal relation with cholestatic jaundice. Hepatic biopsies revealed moderate intrahepatic cholestasis and mild lobular inflammatory infiltration with some eosinophils. No histological evi-dence of acute graft rejection or reactivated hepatitis was found. Treatment with methimazole markedly reduced the serum parameters of cholestasis which, after subtotal thyroidectomy, returned to normal. Liver function recovered. as confirmed by repeated aminopyrine breath tests.

Original language	English
Pages (from-to)	429-432
Number of pages	4
Journal	Digestion
Volume	56
Issue number	5
DOIs	https://doi.org/10.1159/000201271
State	Published - 1995
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cholestasis
Hyperthyroidism
Liver transplantation

Access to Document

10.1159/000201271

Cite this

@article{11c0e22fadc14f15b4388238dc94a114,

title = "Cholestasis induced by hyperthyroidism after liver transplantation",

abstract = "We report the case of a 68-year-old woman who underwent liver transplantation because of hepatitis-C-induced cirrhosis. She developed iodine-induced hyperthyroidism postoperatively in temporal relation with cholestatic jaundice. Hepatic biopsies revealed moderate intrahepatic cholestasis and mild lobular inflammatory infiltration with some eosinophils. No histological evi-dence of acute graft rejection or reactivated hepatitis was found. Treatment with methimazole markedly reduced the serum parameters of cholestasis which, after subtotal thyroidectomy, returned to normal. Liver function recovered. as confirmed by repeated aminopyrine breath tests.",

keywords = "Cholestasis, Hyperthyroidism, Liver transplantation",

author = "Christian Lersch and Markus Seige and Walter Natrath and Wolfgang Heidecke and Christian Wittekind and Meinhard Classen and Wolfgang Schepp",

year = "1995",

doi = "10.1159/000201271",

language = "English",

volume = "56",

pages = "429--432",

journal = "Digestion",

issn = "0012-2823",

publisher = "S. Karger AG",

number = "5",

}

TY - JOUR

T1 - Cholestasis induced by hyperthyroidism after liver transplantation

AU - Lersch, Christian

AU - Seige, Markus

AU - Natrath, Walter

AU - Heidecke, Wolfgang

AU - Wittekind, Christian

AU - Classen, Meinhard

AU - Schepp, Wolfgang

PY - 1995

Y1 - 1995

N2 - We report the case of a 68-year-old woman who underwent liver transplantation because of hepatitis-C-induced cirrhosis. She developed iodine-induced hyperthyroidism postoperatively in temporal relation with cholestatic jaundice. Hepatic biopsies revealed moderate intrahepatic cholestasis and mild lobular inflammatory infiltration with some eosinophils. No histological evi-dence of acute graft rejection or reactivated hepatitis was found. Treatment with methimazole markedly reduced the serum parameters of cholestasis which, after subtotal thyroidectomy, returned to normal. Liver function recovered. as confirmed by repeated aminopyrine breath tests.

AB - We report the case of a 68-year-old woman who underwent liver transplantation because of hepatitis-C-induced cirrhosis. She developed iodine-induced hyperthyroidism postoperatively in temporal relation with cholestatic jaundice. Hepatic biopsies revealed moderate intrahepatic cholestasis and mild lobular inflammatory infiltration with some eosinophils. No histological evi-dence of acute graft rejection or reactivated hepatitis was found. Treatment with methimazole markedly reduced the serum parameters of cholestasis which, after subtotal thyroidectomy, returned to normal. Liver function recovered. as confirmed by repeated aminopyrine breath tests.

KW - Cholestasis

KW - Hyperthyroidism

KW - Liver transplantation

UR - https://www.scopus.com/pages/publications/0029155654

U2 - 10.1159/000201271

DO - 10.1159/000201271

M3 - Article

C2 - 8549888

AN - SCOPUS:0029155654

SN - 0012-2823

VL - 56

SP - 429

EP - 432

JO - Digestion

JF - Digestion

IS - 5

ER -

Cholestasis induced by hyperthyroidism after liver transplantation

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this